Autophagy in Health and Disease -

Autophagy in Health and Disease

Potential Therapeutic Approaches

Kursad Turksen (Herausgeber)

Buch | Hardcover
XI, 177 Seiten
2018 | 1st ed. 2018
Springer International Publishing (Verlag)
978-3-319-98145-1 (ISBN)
160,49 inkl. MwSt
This timely volume explores the impact of autophagy in various human diseases, emphasizing the cell biological aspects and focusing on therapeutic approaches to these diseases. 
The chapters cover autophagy and its potential applications on diseases ranging from obesity, osteoarthritis, pulmonary fibrosis, and inflammation, through ALS, Parkinson's, retinal degeneration, breast cancer, alcoholic liver disease and more. The final chapters round out the book with a discussion of autophagy in drug discovery and 'bench to bedside'. Chapters are contributed by leading authorities and describe the general concepts of autophagy in health and disease, marrying cell biology and pharmacology and covering: studies derived from preclinical experiments, manufacturing considerations,and regulatory requirements pertaining to drug discovery and manufacturing and production. This volume will be useful for basic scientists as well as already practicing cliniciansand advanced graduate students.

Kursad Turksen received his Ph.D. from the University of Toronto in Toronto, Canada in the area of osteoprogenitor biology and cell selection methodologies. He completed his postdoctoral training at the Howard Hughes Medical Institute, University of Chicago, in Chicago, Illinois, studying epidermal biology through use of genetically-altered mouse models. He joined the Ottawa Hospital Research Institute in Ottawa, Canada [previously known as the Loeb Research Institute] where he rose to the position of Senior Scientist in the Division of Regenerative Medicine. His research interests focus on stem cell biology, with a particular interest in the Claudin family of tight junction proteins and their role in epidermal lineage commitment and progression during development in health and disease. Dr. Turksen was, until recently, Editor in Chief of the Springer journal Stem Cell Reviews and Reports and currently serves as Series Editor for the Springer series Stem Cell Biology and Regenerative Medicine.

Autophagy and Stem cells.- Fine-Tuning the Stem Cell Fate by Autophagy.- Role of Autophagy in Aging of Hematopoietic Stem Cells and Their Niche: Relevance in Clinical Transplantations and Regenerative Medicine.- Forkhead box O (FoxO) Transcription Factors in Autophagy, Metabolic Health, and Tissue Homeostasis.- The Role of mTOR in Osteoclasts.- Apoptotic Cell Clearance in Gut Tissue-Role of Intestinal Regeneration.- Autophagic Regulation of Cardiomyocyte Survival and Heart Regeneration.- The Role of Autophagy in Mesenchymal Stem Cell-Based Suppression of Immune Response.- Emerging Connections: Presynaptic Autophagy in Brain Aging and Neurodegenerative Diseases.- Virus and Autophagy: Enemies or Allies.- Cancer Stem Cells and Autophagy: Present Knowledge and Future Perspectives.

"This is a useful supplement for those studying autophagy and provides important perspectives in basic and translational science. It summarizes the known roles of this process in human biology and provides a current outlook on how a better understanding of autophagy will lead to advances in many areas of medicine." (Thomas Bodenstine, Doody's Book Reviews, May 03, 2019)

Erscheinungsdatum
Reihe/Serie Stem Cell Biology and Regenerative Medicine
Zusatzinfo XI, 177 p. 28 illus., 26 illus. in color.
Verlagsort Cham
Sprache englisch
Maße 155 x 235 mm
Gewicht 445 g
Themenwelt Studium 1. Studienabschnitt (Vorklinik) Biochemie / Molekularbiologie
Naturwissenschaften Biologie Mikrobiologie / Immunologie
Naturwissenschaften Biologie Zellbiologie
Naturwissenschaften Chemie Technische Chemie
Schlagworte aging • Cell Cycle Analysis • Diabetes • Metabolic disease • mitochondria • Neurodegeneration • Osteoarthritis
ISBN-10 3-319-98145-5 / 3319981455
ISBN-13 978-3-319-98145-1 / 9783319981451
Zustand Neuware
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