The Role of Microenvironment in the Control of Tumor Angiogenesis - Domenico Ribatti

The Role of Microenvironment in the Control of Tumor Angiogenesis

Buch | Softcover
XI, 86 Seiten
2018 | 1. Softcover reprint of the original 1st ed. 2016
Springer International Publishing (Verlag)
978-3-319-80222-0 (ISBN)
106,99 inkl. MwSt

This work describes the importance of tumor microenvironment in favouring tumor progression and angiogenesis.

Under physiological conditions, angiogenesis is dependent on the balance of positive and negative angiogenic modulators within the vascular microenvironment and requires the functional activities of a number of molecules, including angiogenic factors, extracellular matrix proteins, adhesion molecules and proteolytic enzymes.

In normal tissues, vascular quiescence is maintained by the dominant influence of endogenous angiogenesis inhibitors over angiogenic stimuli.

Tumor angiogenesis is linked to a switch in the balance between positive and negative regulators, and mainly depends on the release by inflammatory or neoplastic cells of specific growth factors for endothelial cells, that stimulate the growth of the blood vessels of the host or the down-regulation of natural angiogenesis inhibitors.

In particular, the inflammatory infiltrate may contribute to tumor angiogenesis, and there are many reports of associations between tumor inflammatory infiltrate, vascularity and prognosis.

New therapeutic approaches have been developed with the aim to control tumor angiogenesis through targeting of different components of tumor microenvironment.     


Prelims.- Tumor microenvironment.- Tumor blood vessels and tumor endothelial cells.- Tumor angiogenesis.- Inflammatory cells in tumor microenvironment.- Therapeutic strategies, the concept of "normalization" and the role of VEGF inhibition.- Index.

 

Erscheinungsdatum
Zusatzinfo XI, 86 p. 28 illus., 16 illus. in color.
Verlagsort Cham
Sprache englisch
Maße 155 x 235 mm
Gewicht 169 g
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Studium 2. Studienabschnitt (Klinik) Pathologie
Schlagworte angiogenesis • anti-angiogenesis • pharmacotherapy • tumor growth • tumor microenvironment • tumor progression
ISBN-10 3-319-80222-4 / 3319802224
ISBN-13 978-3-319-80222-0 / 9783319802220
Zustand Neuware
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