Sesquiterpene Lactones (eBook)

Prof. Dr. Valeria P. Sülsen: Valeria P. Sülsen has a Pharmacy B.Sc. (1998) and Ph.D. (2009) from University of Buenos Aires, Argentina. She got a Posdoctoral Research Fellowship at the Institute of Chemistry and Metabolism of Drugs (IQUIMEFA), University of Buenos Aires – National Scientific and Technical Research Council (CONICET) from 2009 to 2011. In 2011, she received the “Felix de Azara” Award for the best work on flora and fauna of Argentina (Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina) and the Award for the Best Thesis (Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina), in 2009. Nowadays she is a Researcher of The National Scientific and Technical Research Council working at Institute of Chemistry and Metabolism of Drugs (IQUIMEFA) – University of Buenos Aires and member of the research network Natural Products against Neglected Diseases (NPND). She is Assistant Professor of Pharmacognosy, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina. Her main expertise areas are pharmacognosy and antiprotozoal natural products. Prof. Dr. Virginia S. Martino: She has a Pharmacy B.Sc. (1970) and Ph.D. (1983) from University of Buenos Aires, Argentina. Specialist in Policy and Management of Science and Technology (2011). She joined the National Scientific and Technical Research Council in 1982 working at the Institute of Chemistry and Metabolism of Drugs (IQUIMEFA) – Faculty of Pharmacy and Biochemistry-University of Buenos Aires. She is member of the National Academy of Pharmacy and Biochemistry (Argentina).  Awards received: “Felix de Azara” (Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina) (1984, 1989, 2011); Dr. Bernardo Houssay (2003)(CEDIQUIFA); Dr. Alfredo Bandoni (1993) (National Academy of Pharmacy and Biochemistry). She was Head Professor of Pharmacognosy at the Faculty of Pharmacy and Biochemistry, University of Buenos Aires between 2005 and 2014.  

 PART I- CHEMICAL AND BIOCHEMICAL ASPECTS 1. Sesquiterpene lactones. Overview (V. Sülsen, V. Martino - Argentina) 2. Taxonomy (G. Giberti) 3. Biosynthesis and biotechnology (M. Perassolo, J. Rodriguez Talou- Argentina) 4. Chemistry (Francis Barrios - USA) 4.1. Synthesis of sesquiterpene lactones 4.2. Chemical transformation of sesquiterpene lactones 5. Analytical procedures (V. Sülsen, V. Martino, C. Catalán - Argentina; S.M. Adekenov- Kazakhstan) 5.1. Extraction and isolation 5.2. Identification. Spectroscopic methods PART II- BIOLOGICAL ACTIVITIES 6. Trypanocidal and leishmanicidal activities (S. Cazorla, A. Bivona, N. Cerny - Argentina) 7. Mode of action of sesquiterpene lactones on Trypanosoma and Leishmania spp. , (E. Lombardo, M. Sosa, E. Lozano, P. Barrera, R. Spina - Argentina) 7.1. Molecular targets 7.2. Contribution of microscopy for understanding the mechanism of action of sesquiterpene lactones 8. Effect of sesquiterpene lactones on other microorganisms (antibacterial, antifungal, antiviral and antiplasmodial) (authorship to confirm) 9. Antiproliferative and cytotoxic activities (C. Anesini, R. Martino - Argentina) 10. Anti-inflammatory activity (M.R. Alonso) PART III- SESQUITERPENE LACTONES: MEDICINAL CHEMISTRY APPROACH 11. Structure-activity relationship (T. Schmidt - Germany) 11.1. Structure -antiprotozoal activity relationship 11.2. Structure -antiproliferative activity relationship 11.3. Structure -anti-inflammatory activity relationship (authorship to confirm)