Immunotherapy in Translational Cancer Research (eBook)

Laurence J. N. Cooper, Associate Professor, Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, USA. Elizabeth A. Mittendorf, Professor, Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA. Judy Moyes, Department of Pediatric Research, The University of Texas MD Anderson Cancer Center, Houston, USA. Sabitha Prabhakaran, Clinical Research Scientist, Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.

Editors vi

Contributors vii

Introduction ix

1 Translation in Immunology: The Role of Translational Biomarkers to Guide Clinical Use of Immunotherapy for Cancer 1
Saranya Chumsri and Keith L. Knutson

2 Monoclonal Antibody Therapy 12
Elizabeth A. Mittendorf and Sabitha Prabhakaran

3 Somatic Mutations and Immunotherapy 24
Eric Tran

4 Checkpoint Blockade 37
Tracy A. Proverbs-Singh Jedd Wolchok and Alexandra Snyder

5 Myeloid Leukemia Vaccines 54
Paul M. Armistead and Jonathan S. Serody

6 Cancer Vaccines for Solid Tumors 72
Timothy J. Vreeland Garth S. Herbert and George E. Peoples

7 Immunotherapy with Non-Genetically Modified T Cells 91
Cassian Yee

8 Immunotherapy with Genetically Modified T Cells 101
Liora Schultz and Crystal Mackall

9 Immunomodulation with Adjuvants and Cytokines 115
Dae won Kim and Adi Diab

10 Immune Cell Migration in Cancer and Immunotherapy 132
Timothy Murray and Daniel E. Speiser

11 Repurposing of Drugs for Immunotherapy 143
Jyothishmathi Swaminathan and Vidya Gopalakrishnan

12 Immunomodulation with Radiation 161
Jonathan E. Schoenhals Taylor R. Cushman, Alexandra P. Cadena Sandra Demaria and James W. Welsh

13 Good Manufacturing Practices Facilities for Cellular Therapy 177
Andrew D. Fesnak and Bruce L. Levine

14 T Cell Receptor Mimic Antibodies 186
Gheath Alatrash and Jeffrey J. Molldrem

15 Stem Cell Transplantation for Treatment of Malignancy 201
Lohith S. Bachegowda and Richard E. Champlin

16 Natural Killer Cell-Based Immunotherapy 215
Jennifer A. Foltz Jeffrey S. Miller and Dean A. Lee

17 Immunologic Monitoring in Immuno-Oncology 228
William R. Gwin and Mary L. Disis

18 Cell-Based Therapies for Canine Cancer 252
Nicola J. Mason and M. Kazim Panjwani

19 Interaction between Targeted Therapy and Immunotherapy 268
Peter A. Prieto Miles C. Andrews, Alexandria P. Cogdill, and Jennifer A. Wargo

Index 286