Experimental Life Prolongation

PREFACE. MECHANISMS OF AGING. ADAPTATION-REGULATION THEORY. Phylogenesis, Ontogenesis, Etagenesis. Aging Syndromes. Aging and Diseases. GENOREGULATORY MECHANISMS OF AGING. Genome Regulation. Intracellular Regulation. Neurohormonal Control. CELL FUNCTION. Sequence of Cellular Aging. Electrophysiologic Changes. Lability. Ionic Transport Systems. Lipids of Plasmatic Membrane. Membrane-Genome Relations. NEUROHUMORAL MECHANISMS OF AGING. Brain Integrative Activity. Limbic System and Hypothalamus. Neurotrophic Mechanisms. Hormonal Regulation. Feedbacks in the System of Neurohormonal Regulation. Reactivity of Effectors. MODELS OF LIFESPAN. EVOLUTION AND LIFESPAN. Genome. Unicellates and Cell Culture. Organism. CORRELATORS OF SPECIES-SPECIFIC LIFESPAN. Genome. Morphophysiological Parameters. Mechanisms of Vitauct. KINETICS AND MATHEMATICAL MODELS OF MORTALITY. Exponential Models. Conceptual Models. BIOLOGICAL MODELS. Protozoa. Fungi. Plants. Animals. Cell Culture. MEANS OF LIFE PROLONGATION. DIETARY FACTORS. Cold-Blooded. Laboratory Mammals. Man. INHIBITORS AND ACTIVATORS OF PROTEIN SYNTHESIS. Inhibitors of Transcription. Inhibitors of Translation. Influence of Olivomycin on Aging of Rats. Inhibitors of Mitochondrial Replication and Protein Biosynthesis. Polyamines. ENTEROSORPTION. TEMPERATURE. Cold-Blooded. Mammals. Man. IONIZING RADIATION. Geropromotoring Effects. Hormetic Effects. ANTIOXIDANTS. Cold-Blooded. Mammals. Man. MOTOR ACTIVITY. Laboratory Insects. Mammals. Man. FACTORS OF NEUROHUMORAL REGULATION. Cold-Blooded. Mammals. Man. PHYSICAL FACTORS. MICROELEMENTS. Cold-Blooded. Mammals. Man. BIOLOGICALLY ACTIVE SUBSTANCES. Vitamins. Adaptogens. Revitalizators. Immune System Modulators. Membrane Stabilizers. Lathyrogens and Modificators of Connective Tissue. Other Biologically Active Substances. CONCLUSION. c. 432 pp., 94 illus., 7x10, due August 1991, ISBN 0-8493-6741-7.