Polyendocrine Disorders and Endocrine Neoplastic Syndromes

Annamaria Colao is a professor at "Federico II" University of Naples and chief of the Neuroendocrine Unit, University Federico II, Naples, Italy. Her current areas of research include the molecular basis and clinical treatment of neuroendocrine tumors and tumors in the hypothalamus/pituitary region, the consequences of deficiency and excess of GH and IGF-I for the cardiovascular system, endocrine consequences in survivors of malignant neoplasia, and insulin resistance and cancer. Dr. Colao is a member of numerous medical societies, including the Italian Society of Endocrinology, the European Neuroendocrine Association, and the European Society of Endocrinology. She is the author of more than 500 peer-reviewed publications.

Introduction.-Auto-immune polyglandular syndromes (APS): an overview.- The natural history of APS1: pathogenesis and long term follow-up.- The genetics of AIRE: an update.- Auto-antibodies in polyendocrine auto-immune disorders: an update.- Rare forms of endocrine and systemic auto-immune disorders: IPEX and "other POEMS".- Auto-immune endocrine diseases and cancer immunotherapy.- Part 2: MEN1: an update on molecular diagnosis and clinical implications.- MEN2: an update on molecular diagnosis and clinical implications.- MEN4 and other MEN1-like syndrome.- Genetic alterations in the cAMP pathway: MAS, Carney complex (and AIP?).- Endocrine tumours associated with SDHx mutations: pheochromocytomas, paragangliomas and pituitary adenomas.- Endocrine tumours in complex genetic disorders: lessons from pheochromocytomas and hyperparathyroidism.