Cell Therapy for Perinatal Brain Injury -

Cell Therapy for Perinatal Brain Injury (eBook)

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2018 | 1st ed. 2018
XII, 150 Seiten
Springer Singapore (Verlag)
978-981-10-1412-3 (ISBN)
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This book provides a wealth of insights, advances and new perspectives on cell therapy for different types of neonatal ischemic disease, such as Hypoxic-Ischemic Encephalopathy (HIE), Periventricular Leukomalacia (PVL) and neonatal infarction.

These diseases pose serious challenges for neonatologists and neurologists, because the severe sequelae lead to decreasing QOL for patients and their families. Accordingly, new treatments for neonatal ischemic diseases are needed all over the world.

The book develops new effective therapies combined with hypothermia therapy, an established treatment for HIE. After reviewing past approaches, it presents cutting-edge topics in cell therapy, one of the most promising candidates for treating neonatal ischemic disease. Cell Therapy for Neonatal Ischemic Disease will offer readers a better understanding of the current state of the art in this field from bench to bedside, and inspire researchers and physicians to further explore this evolving therapy.



Haruo Shintaku
Department of Pediatrics,
Osaka City University Graduate School of Medicine,
Osaka
Japan

Akira Oka
Department of Pediatrics,
University of Tokyo, 
Tokyo
Japan

Makoto Nabetani, 
Department of Pediatrics,
Yodogawa Christian Hospital, 
Osaka,
Japan

This book provides a wealth of insights, advances and new perspectives on cell therapy for different types of neonatal ischemic disease, such as Hypoxic-Ischemic Encephalopathy (HIE), Periventricular Leukomalacia (PVL) and neonatal infarction. These diseases pose serious challenges for neonatologists and neurologists, because the severe sequelae lead to decreasing QOL for patients and their families. Accordingly, new treatments for neonatal ischemic diseases are needed all over the world. The book develops new effective therapies combined with hypothermia therapy, an established treatment for HIE. After reviewing past approaches, it presents cutting-edge topics in cell therapy, one of the most promising candidates for treating neonatal ischemic disease. Cell Therapy for Neonatal Ischemic Disease will offer readers a better understanding of the current state of the art in this field from bench to bedside, and inspire researchers and physicians to further explore this evolving therapy.

Haruo ShintakuDepartment of Pediatrics,Osaka City University Graduate School of Medicine,OsakaJapanAkira OkaDepartment of Pediatrics,University of Tokyo, TokyoJapanMakoto Nabetani, Department of Pediatrics,Yodogawa Christian Hospital, Osaka,Japan

1. Clinical trial of autologous cord blood cell therapy for neonatal hypoxic‐ischemic encephalopathy (HIE).- 2. New strategy of clinical studies for premature babies with ischemic brain damage .- 3. Pathophysiology and pathology of neonatal hypoxic-ischemic encephalopathy.- 4. Neural stem/progenitor cells for perinatal brain injury.- 5. Hematopoietic stem cells for perinatal brain injury.- 6. Umbilical cord-derived mesenchymal stromal cells for perinatal brain injury.- 7. Other tissues-derived mesenchymal stem cells for perinatal brain injury.- 8. CD34+ cell in cord blood and neonates.- 9. The History of Hypothermia therapy for perinatal ischemic brain injury.- 10. Clinical Procedure of Cell Therapy (Cord blood collection).- 11. Clinical Procedure of Cell Therapy (Separation and infusion).- 12. Cell therapy for adult infarction.- 13. Clinical trials on cell therapy for perinatal brain injury: Challenges and opportunities.- 14. A new prospective cell therapy for neonatal brain injury.

Erscheint lt. Verlag 1.3.2018
Zusatzinfo XII, 150 p.
Verlagsort Singapore
Sprache englisch
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Gynäkologie / Geburtshilfe
Medizin / Pharmazie Medizinische Fachgebiete Neurologie
Medizin / Pharmazie Medizinische Fachgebiete Pädiatrie
Schlagworte CD34 cell • clinical trial • Ischemic disease • mesenchymal stem cell • Neural stem cell • Stem Cell Therapy
ISBN-10 981-10-1412-4 / 9811014124
ISBN-13 978-981-10-1412-3 / 9789811014123
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