Vitiligo (eBook)

About the Editors Somesh Gupta, MD, DNB, MNAMS, Professor, Department of Dermatology & Venereology, All India Institute of Medical Sciences, New Delhi, India Mats J. Olsson, MD, PhD, CEO, ParkCell AB and President, International Vitiligo Center, Uppsala, Sweden Davinder Parsad, MD, Professor, Department of Dermatology, Venereology & Leprology, Postgraduate Institute of Medical Education & Research, Chandigarh, India Henry W. Lim, MD, Chair Emeritus, Department of Dermatology and Senior Vice President for Academic Affairs, Henry Ford Health System. Past President, American Academy of Dermatology, Detroit, USA Nanja van Geel, MD, PhD, Professor, Department of Dermatology, Ghent University Hospital, Ghent, Belgium Amit G. Pandya, MD, Professor, Department of Dermatology, University of Texas, Southwestern Medical Center, Dallas, USA

Table of Contents

List of Contributors

1 Introduction

2 Melanocyte and melanogenesis: Applied anatomy and physiology

3 Epidemiology of Vitiligo

4 Pathogenesis of vitiligo

5 Understanding the mechanisms of repigmentation in vitiligo

6 Classification and Clinical Features of vitiligo

7 Outcome Measures for Vitiligo

8 Evaluation and treatment of the psychosocial burden of vitiligo

9 Patient support, education and compliance

10 Goals of Vitiligo Treatment, and Evidence Based Practice Guidelines for Medical and Surgical Management

11 The concept of stability of vitiligo and stabilization therapies

12 Narrowband Ultraviolet B Phototherapy in Vitiligo

13 UVA-based Phototherapy: PUVA, PUVA-sol, UVA1 phototherapy

14 Immunomodulators and immunosuppressives in Vitiligo

15 Topical Glucocorticoids, Topical Calcineurin Inhibitors and Topical Vitamin D3 Analogues

16 Targeted Phototherapy in Vitiligo

17 OTHER THERAPIES IN VITILIGO

18 Biologic therapies for vitiligo

19 Evidence toward integrated management of Vitiligo combining Ayurveda and Homeopathy with Modern Dermatology

20 History and chronology of development of surgical therapies for vitiligo

21 Patient selection, pre and postoperative information in surgical therapies for vitiligo

22 Classification of surgical therapies for vitiligo

23 Minigrafting for vitiligo

24 Suction blister epidermal grafting

25 Thin and ultra-thin skin grafts for vitiligo

26 Treatment of leukoderma by transplantation of ultra-thin epidermal sheets

27 Surgical management of leukotrichia

28 Mesh grafting in vitiligo

29 Smash Grafting

30 Therapeutic Needling and Needling Micrografting

31 Complications and limitations of melanocyte transplantation

32 Treatment of leukoderma by transplantation of basal cell layer suspension

33 Non cultured extracted follicle outer root sheath cell suspension transplantation

34 Long term results of non cultured epidermal cellular grafting in vitiligo

35 Simplified Non-Cultured Cellular Grafting

36 Novel methods of preparing epidermal cell suspension for transplantation in vitiligo

37 Setting up a tissue culture laboratory

38 Treatment of leukoderma by transplantation of cultured autologous melanocytes

39 Transplantation of in-vitro cultured epithelial grafts for vitiligo and piebaldism

40 Application of lasers for abrasion in transplantation procedures for vitiligo

41 Cell delivery on recipient skin

42 Safety concerns in transplantation of in vitro cultured cellular grafts

43 Surgical management of lip vitiligo, eyelids and genitals

44 Surgical management of acral vitiligo

45 Surgical management of leukotrichia

46 Surgical treatments of leukodermas other than vitiligo vulgaris

47 Ethnic issues in management and Sun protection

48 Management Issues for Vitiligo in Children and Pregnant Women

49 Combination treatments for Vitiligo

50 Micropigmentation

51 CAMOUFLAGE IN VITILIGO

52 Depigmentation treatment for vitiligo: bleaching cream, laser and cryotherapy

53 Future directions in medical and surgical management of vitiligo

54 Informed consent