Polyphenols: Mechanisms of Action in Human Health and Disease

Ronald Ross Watson, PhD, is Professor of Health Promotion Sciences at the University of Arizona, Mel and Enid Zuckerman College of Public Health. Dr. Watson began his research in public health at the Harvard School of Public Health as a Fellow in 1971 doing field work on vaccines in Saudi Arabia. He has done clinical studies in Colombia, Iran, Egypt, Saudi Arabia and the United States which provides a broad international view of public health. He has served in the military reserve hospital for 17 years with extensive training in medical responses to disasters as the chief biochemistry officer of a general hospital, retiring as a Lt. Colonel. He is a distinguished member of several national and international nutrition, immunology, and cancer societies. Dr. Watson’s career has involved studying many lifestyle aspects for their uses in health promotion. He has edited over 100 biomedical reference books and 450 papers and chapters. His teaching and research focuses on alcohol, tobacco, and drugs of abuse in heart function and disease in mouse models. Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRSC, FRCPath graduated with an Honours Degree in Biology and Physiology with Pharmacology. After gaining his University of London PhD, he received his Membership of the Royal College of Pathologists. He was later awarded his second doctorate (DSc), for his contribution to protein metabolism in health and disease. He is Professor of Clinical Biochemistry (Hon) at King’s College Hospital and Emeritus Professor of Nutritional Biochemistry at King’s College London. He has Honorary Professorships at the University of Hull, and the University of Suffolk. Professor Preedy was the Founding Director and then long-term Director of the Genomics Centre at King’s College London from 2006 to 2020. Professor Preedy has been awarded fellowships of the Royal Society of Biology, the Royal College of Pathologists, the Royal Society for the Promotion of Health, the Royal Institute of Public Health, the Royal Society for Public Health, the Royal Society of Chemistry and the Royal Society of Medicine. He carried out research when attached to the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with international research groups in Finland, Japan, Australia, USA, and Germany. To his credit, Professor Preedy has published over 750 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and edited books. Dr. Sherma Zibadi received her Ph.D. in Nutritional Sciences from the University of Arizona. Her medical degree and training were done at the Mashhad University of Medical Sciences. She then completed her post-doctoral research fellowship awarded by the American Heart Association where her research involved cardiology and complementary medicine studies. Her research has involved maladaptive cardiac remodeling process, which helps to identify new targets for treatment of heart failure. Dr. Zibadi’s research interest also extends into foods as medicines, exploring the preventive and therapeutic effects of dietary supplements on heart failure and its major risk factors in both basic animal and clinical studies, translating lab research findings into clinical practice. Dr. Zibadi is an author of more than 35 research papers in peer reviewed journals. She has been an editor on 8 scientific books like this one being proposed. She has edited on a variety of clinical topics: breast milk, bottle feeding, wheat and rice in health, polyphenols and health, omega 3 fatty acids, dietary supplements in immune modulation, and dietary fat and health. She and Dr. Watson have collaborated extensively on both laboratory research and editing.

1. Polyphenols in the Prevention of Acute Pancreatitis in Preclinical Systems of Study: A Revisit
2. Polyphenols as Supplements in Foods and Beverages: Recent Discoveries and Health Benefits, an Update
3. Xanthohumol and the Medicinal Benefits of Beer
4. Polyphenolic Flavonoids and Metalloprotease Inhibition: Applications to Health and Disease
5. Biological and Pharmacological Effects of Polyphenolic Compounds From Ecklonia cava
6. Clerodendrum volubile: Phenolics and Applications to Health
7. Eryngium campestre L.: Polyphenolic and Flavonoid Compounds; Applications to Health and Disease
8. Antioxidant Activity of Anthocyanins in Common Legume Grains
9. Tomato Polyphenolics: Putative Applications to Health and Disease
10. Polyphenolic Compounds in Sweet Cherries: A Focus on Anthocyanins
11. Citrus Fruit Polyphenols and Flavonoids: Applications to Psychiatric Disorders
12. Anthocyanins and Diabetes Regulation
13. The Role of Direct and Indirect Polyphenolic Antioxidants in Protection Against Oxidative Stress
14. Role of Protocatechuic Acid in Obesity-Related Pathologies: An Update
15. Exposure to Polyphenolic Compounds Modulates Type 1 Diabetes: The Case of Genistein
16. Chocolate/Cocoa Polyphenols and Oxidative Stress
17. An Overview of Dietary Polyphenols and Their Therapeutic Effects
18. The Polyphenolic Compound Resveratrol Attenuates Pain: Neurophysiological Mechanisms
19. Possible Benefits and Risks of Polyphenols Supplementation During Pregnancy
20. Flavonoids as Modulators of Neutrophils’ Oxidative Burst: Structure-Activity Relationship
21. Manipulation of Mitochondrial Function by Polyphenols for New Treatment Strategies
22. Bioavailability of Flavonoids: The Role of Cell Membrane Transporters
23. Interaction of Polyphenols with the Intestinal and Placental Absorption of Some Bioactive Compounds
24. Analyzing Ingredients in Dietary Supplements and Their Metabolites
25. Metabolism of Dietary Polyphenols by Human Gut Microbiota and Their Health Benefits
26. Bioavailability and Biochemistry of Quercetin and Applications to Health and Diseases
27. Effects of Quercetin and Its Combinations on Health
28. Green Tea Polyphenols in the Amelioration of Osteoarthritis: Memoir on the Preclinical Observations
29. Polyphenolics Evoke Healing Responses: Clinical Evidence and Role of Predictive Biomarkers 403
30. Hepatoprotective Effects of Green Tea and Its Polyphenols: A Revisit
31. CAPE and Tympanosclerosis
32. The Polyphenolic Compound Hesperidin and Bone Protection