Estrogens and Antiestrogens
Lippincott Williams and Wilkins (Verlag)
978-0-397-51719-0 (ISBN)
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This volume provides an up-to-date and comprehensive review of the basic and clinical aspects of tissue selective estrogens and antiestrogens. It covers all the major organ systems in which estrogen deficiency produces clinical entities that are likely to respond to tissue selective estrogens. The book is particularly timely because of the extensive clinical trials now in progress of new antiestrogens. The introductory section examines the chemistry, structure-function relationships, pharmacokinetics and pharmacodynamics, clinical pharmacology, and cellular actions of estrogens and antiestrogens and the clinical consequences of postmenopausal estrogen deficiency. Subsequent sections discuss the effects of estrogens and antiestrogens on the central nervous system, the cardiovascular system, bone and mineral metabolism, the breast, and the reproductive and urogenital tracts. Each of these sections contains a basic science chapter and a clinically oriented chapter. The concluding chapter explores the potential role of estrogens and antiestrogens in the treatment of postmenopausal women
Part I Structure and function: history of the oestrogen receptor concept and its relation to anti-oestrogens; the origin of anti-oestrogens; chemistry - structure/function relationships; metabolism of anti-oestrogens; mode of action at the cellular level with specific reference to bone cells; the postmenopausal state and oestrogen deficiency. Part II Target issues: oestrogenic effects on the central nervous system - clinical aspects; effects on the cardiovascular system - basic aspects; effects on the cardiovascular system - clinical aspects; effects on bone and mineral metabolism - basic aspects; clinical effects of oestrogens and anti-oestrogens on the skeleton and skeletal metabolism; clinical implications of target organ specific actions of selective anti-oestrogens; effects on breast tissue - clinical aspects; oestrogenic and anti-oestrogenic actions of tamoxifen in the female reproductive tract - clinical aspects; oestrogens and anti-oestrogens and the urogenital tract. Part III Future opportunities: the complexity of selective oestrogen receptor modulation - design of a postmenopausal prevention maintenance therapy.
Erscheint lt. Verlag | 1.8.1998 |
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Zusatzinfo | 7 halftones, 88 line illustrations, 26 tables |
Verlagsort | Philadelphia |
Sprache | englisch |
Maße | 178 x 254 mm |
Gewicht | 760 g |
Themenwelt | Medizin / Pharmazie ► Medizinische Fachgebiete ► Gynäkologie / Geburtshilfe |
Medizinische Fachgebiete ► Innere Medizin ► Endokrinologie | |
ISBN-10 | 0-397-51719-X / 039751719X |
ISBN-13 | 978-0-397-51719-0 / 9780397517190 |
Zustand | Neuware |
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