Enzymatic Peptide Synthesis

1. Introduction 2. Reversible Zymo-Hydolysis - A Chronology of Enzymatic Peptide Synthesis 3. Thermodynamic Aspects of Peptide Bond Synthesis 4. Formation of Peptide Bonds - Proteases as Activating Systems 5. Proteosynthesis vs. Proteolysis: How to Bias This Antagonism in Favor of Proteosynthesis 6. Advantages of Enzymatic Peptide Synthesis 7. Proteases as Biocatalysts for the Synthesis of Model Peptides 8. Enzymatic Synthesis of Biologically Active Peptides 9. Protease-Catalyzed Oligomerization 10. Protease-Catalyzed Semisynthesis 11. Kinetics of Protease-Controlled Synthesis of Peptide Bonds 12. Proteases as Catalysts in Protecting Group Chemistry 13. Shortcomings and Alternatives 14. Synopsis and Prognosis