Formaldehyde

For the past two decades, my research has focused on understanding the molecular mechanisms of bone marrow toxicity caused by benzene and other toxic chemicals, including butadiene, formaldehyde, tricholoroethylene, and arsenic. Our investigations have mainly involved the detection of biomarkers associated with these chemical exposures in molecular epidemiological studies. We investigated specific chromosomal aneuploidies and rearrangements in many of these studies, as well as in mature and progenitor human cells by a molecular cytogenetic method named FISH (fluorescence in situ hybridization). To identify additional novel biomarkers and disease-related mechanisms associated with these chemical exposures, we have developed and continue to employ many high-throughput technologies, such as single-cell genetic analysis (SCGA), advanced omic-based methodologies, next-generation sequencing (NGS), RNAi (RNA interference), and, most recently, CRISPR-Cas9. Besides my long-term involvement and contributions to the Northern California Childhood Leukemia Study (NCCLS), I have been a co-project leader and/or co-principal investigator in the Center for Interdisciplinary Research on Childhood Leukemia and the Environment (CIRCLE), the Superfund Basic Research Program (SBRP), and the Center for Exposure Biology (CEB) at Berkeley.

Introduction to Formaldehyde;

Formaldehyde Exposure, Regulation, and Metabolism;

Formaldehyde Exposure in China;

General Toxicity of Formaldehyde;

Formaldehyde Carcinogenesis;

Formaldehyde Exposure and Leukemia Risk;

Potential Mechanisms of Formaldehyde-Induced Leukemia;

Formaldehyde Induced Leukemia-Specific Chromosomal Aneuploidy;

Formaldehyde-Associated Brain Tumors;

Formaldehyde-Associated Neurodegenerative Diseases;

Formaldehyde Toxicity in Children;

Reproductive and Developmental Toxicity of Formaldehyde Exposure in Humans;

Reproductive and Developmental Toxicity of Formaldehyde Exposure in Animals;

Mechanisms of Action for Formaldehyde-Induced Reproductive and Developmental Toxicity;

Conclusions and Future Directions