Hematopoietic Stem Cell Transplantation for the Pediatric Hematologist/Oncologist (eBook)

Valerie I. Brown, MD, PhD Director, Experimental Therapeutics, Pediatric Hematology/Oncology Director, Pediatric Hematology/Oncology Fellowship Program Penn State Milton S. Hershey Medical Center and Children’s Hospital, Division of Pediatric Oncology/Hematology, Hershey, PA, USA

Part I. Introduction, History and the Basic Principles of Pediatric Hematopoietic Stem Cell Transplantation (HSCT)1. IntroductionValerie I. Brown2. Historical Overview of Pediatric HSCT Valerie I. Brown3. Brief Introduction to the Basic Scientific Principles of Hematopoietic Stem Cell Transplantation (HSCT)Valerie I. BrownPart II. Topics Related to the Pre- HSCT Period4. Pretransplantation: Indications and TimingAlicia McFarren and Michael A. Pulsipher5. Spotlight on Minimal Residual Disease (MRD): Impact of MRD on HSCT Outcomes for Pediatric LeukemiaAbdel-Azim and Michael A. Pulsipher6. HSCT Recipient Pretransplantation Evaluation Carrie Eichelberger and Valerie I. Brown7. How to Select a Donor and Hematopoietic Stem Cell Source: Related versus Unrelated Donors for Allogeneic HSCT Malika Kapadia and Robert Greiner 8. Donor Evaluation, Selection and Hematopoietic Stem Cell Mobilization, Procurement and Manipulation William Ferguson and Aleksander Babic9. Preparing the Patient for HSCT: Conditioning Regimens and their Scientific Rationale Carrie Kitko, Katie Gatwood, James ConnellyPart III. The Peri- HSCT Period: Pre-Engraftment (Days 0-30) and Early Post- HSCT (Days 30-100) Periods10. Engraftment and Chimerism Valerie I. Brown11. Graft Failure Valerie I. Brown12. Engraftment Syndrome and Associated Cytokine Storm and Capillary Leak Syndrome Mala K. Talekar and Jason L. Freedman13. Nutrition in the Peri-HSCT Period Arun Gurunathan, Judy Bailer, Jason L. Freedman14. Mucositis and Pain in the Peri- HSCT Period Arun Gurunathan, Neil S. Patel, Jason L. Freedman15. Hepatoxicity in the Peri- HSCT Period Valerie I. Brown16. Renal Toxicities in the Peri-HSCT PeriodMalika Kapadia, Terry Shapiro and Robert Greiner17. Infectious Complications and HSCT Karen Bride, Ellen Levy, Anne Wohlschlaeger, Jason L. Freedman18. Acute Graft-Versus-Host Disease: Diagnosis, Prophylaxis, and TreatmentKaren L. Bride, Neil S. Patel, Jason L. FreedmanPart IV. The Late Post- HSCT Period (> 100 Days)19. Chronic GVHD Terry Wikle Shapiro, Malika Kapadia20. Hematologic Complications Associated with HSCT Mala K. Talekar and Timothy Olson21. Pulmonary Complications Associated with HSCT Malika Kapadia and Terry Shapiro22. Renal Complications Associated with HSCT Lena E. Winestone, Alix E. Seif, Benjamin L. Laskin23. Cardiac Complications Associated with HSCT Valerie I. Brown24. Neurologic and Sensory Complications Associated with HSCT Valerie I. Brown25. HSCT-Associated Complications of the Skin, Hair and Nails Valerie I. BrownPart V: Life After HSCT26. Immune Reconstitution after Hematopoietic Stem Cell Transplantation Mala K. Talekar and Timothy Olsen27. Life After HSCT: Survivorship and Long-Term Issues Smita DandekarPart VI. Pharmacologic-Related Issues of Pediatric HSCT28. Medications commonly Used in Pediatric HSCT Kevin Mulieri, Ashley Teusink-Cross, JoEllen Wellnau, Krisoula Horiates, Katie S. Gatwood