Bronchiectasis (eBook)

Dr James D Chalmers is Senior Clinical Lecturer and Consultant Physician at the Scottish Centre for Respiratory Research at the University of Dundee. He runs a large specialist bronchiectasis clinic in the East of Scotland and a research group focussing on the interactions between neutrophil mediated inflammation and bacterial infection in chronic respiratory disease, particularly bronchiectasis and COPD. He is associated editor of the European Respiratory Journal and a member of the international advisory board of the Lancet Respiratory Medicine. He is chair of the European Bronchiectasis Network and Registry (EMBARC).  Eva Polverino is Doctor of Medicine in Cardiopulmonary Pathophysiology from the University of Pisa (Italy). She currently works as postdoctoral clinical researcher at the Hospital Clinic in Barcelona, IDIBAPS. Specialist in respiratory medicine, she is involved in the field of respiratory infections and particularly in Community Acquired Pneumonia (CAP), noncystic fibrosis bronchiectasis (NCFB) and humoral immuno-deficiencies. She investigates epidemiology, risk factors, outcome, treatment and prevention of the most relevant respiratory infections. In the field of bronchiectasis main objectives are focused on investigation of the prevalence and outcomes of this underestimated but very frequent disease, and its impact on the society. The results of her research are aimed at investigating pathogenetic mechanisms of respiratory infections, improving their clinical outcomes and patients’ quality of life.Stefano Aliberti is Associate Professor of Respiratory Medicine at the University of Milan and consultant at the Cardio-Thoracic Unit and Cystic Fibrosis Adult Center at the Policlinico Hospital in Milan, Italy. His research interest is in respiratory infectious diseases, including bronchiectasis, NTM and pneumonia. He has published extensively in this area over the past 10 years as well as co-authoring books and book chapters on respiratory medicine. He is Head of the Respiratory Infection Assembly of the European Respiratory Society. He is chair of EMBARC (European Multicentre Bronchiectasis Audit and Research Collaboration), director of the Italian Registry of Bronchiectasis IRIDE and the Italian Registry of pulmonary NTM IRENE.

Preface.- Introduction.- 1 Radiological diagnosis of bronchiectasis.- 2 Epidemiology and clinical aspects.- 3 Pathophysiology and histopathology of bronchiectasis.- 4 Immunology of bronchiectasis.- 5 How to identify treatable causes and other predisposing factors in bronchiectasis.- 6 Immunodeficit in bronchiectasis.- 7 ENT diseases and bronchiectasis.- 8 Bronchiectasis and ABPA.- 9 COPD and bronchiectasis.- 10 Other predisposing factors for bronchiectasis.- 11 Channelopathies in bronchiectasis.- 12 The severity of the disease and multidisciplinary management.- 13 Pseudomonas aeruginosa in bronchiectasis.- 14 The role of other bacteria, fungi and viruses in bronchiectasis.- 15 NTM in bronchiectasis.- 16 Exacerbation of bronchiectasis.- 17 Long-tern inhaled antibiotic treatment.- 18 Long-term oral antibiotic / anti-inflammatory treatment.- 19 Airway clearance.- 20 Pulmonary rehabilitation.- 21 Nursing management.- 22 Surgery and transplantation in bronchiectasis.- 23 How to manage bronchiectasis in primary care.- 24 An overview of bronchiectasis in children.- Conclusions.