Histiocytic Disorders (eBook)

Oussama Abla, Gritta Janka (Herausgeber)

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2017 | 1st ed. 2018
XII, 392 Seiten
Springer International Publishing (Verlag)
978-3-319-59632-7 (ISBN)

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This volume provides a comprehensive and world-class review of the field of histiocytic neoplasms and hemophagocytic lymphohistiocytosis (HLH). It reviews all the advances in the field of histiocytoses during the last ten years, particularly with regards to the genomic findings in LCH and other histiocytic neoplasms and the new suggested classification of the histiocytic disorders. Additionally, it features a state-of-the art update on the most recent treatment strategies for LCH, including the results of the last LCH-III international trial, salvage therapies such as reduced-intensity conditioning (RIC) stem cell transplant (SCT), and targeted therapies with BRAF and MEK inhibitors, as well as the challenging cases of CNS-neurodegenerative LCH and its therapeutic perspectives. For primary and secondary HLH the book updates the most recent genetic and pathophysiological findings, including macrophage-activation syndrome (MAS), and includes a special chapter on HLH in adults. Treatment chapters encompass therapy for newly diagnosed HLH and refractory disease as well as stem-cell transplantation and novel therapies. The text also highlights the most recent advances in the treatment of the uncommon histiocytic disorders, such as Erdheim-Chester disease (ECD), Juvenile xanthogranuloma (JXG) and JXG-like conditions, Rosai-Dorfman disease (RDD), and the very rare malignant histiocytoses.

Written by international experts in the field, Histiocytic Disorders is a valuable resource for clinicians, researchers, fellows and residents who are interested in or manage histiocytic disorders in children and adults.


Oussama Abla, MD
Chair, Rare Histiocytoses Steering Committee- Histiocyte Society, Associate Professor of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, 
Canada

Gritta Janka, MD, PhD
Chair, HLH Steering Committee, Histiocyte Society, Professor emeritus of Pediatrics, University Medical Center Hamburg Eppendorf, Pediatric Hematology and Oncology, Hamburg, Germany

Oussama Abla, MDChair, Rare Histiocytoses Steering Committee- Histiocyte Society, Associate Professor of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, CanadaGritta Janka, MD, PhDChair, HLH Steering Committee, Histiocyte Society, Professor emeritus of Pediatrics, University Medical Center Hamburg Eppendorf, Pediatric Hematology and Oncology, Hamburg, Germany

Section I Pathology of Histiocytic DisordersChapter 1 Pathology of Histiocytic Disorders and Neoplasms and Related DisordersJennifer Picarsic, Ronald JaffeSection II : Langerhans Cell Histiocytosis (LCH)Chapter 2 Biology and Genomics of LCH and Related DisordersBarrett J. RollinsChapter 3 Epidemiology and Clinical Manifestations of Langerhans Cell Histiocytosis in ChildrenEtai Adam, Rima Jubran, Sheila WeitzmanChapter 4 Central Nervous System Langerhans Cell HistiocytosisMilen Minkov, Jennifer Picarsic, Karoly LakatosChapter 5 First-line Treatment of Pediatric Langerhans Cell HistiocytosisCarlos Rodriguez-Galindo, Cor van den BosChapter 6 Treatment of Relapsed and Refractory Langerhans Cell Histiocytosis in ChildrenOussama Abla, Carlos Rodriguez-Galindo, Paul VeysChapter 7 Adult Langerhans Cell HistiocytosisMichael Girschikofsky, Abdellatif TaziChapter 8 Late Effects of Langerhans Cell Histiocytosis and the Association of LCH with Malignancy Vasanta Nanduri, Lilibeth R. Torno, Riccardo HauptSection III : Hemophagocytic Lymphohistiocytosis (HLH)Chapter 9 Classification, Clinical Manifestations and Diagnostics of HLHJana Pachlopnik Schmid, Benjamin Volkmer, Stephan EhlChapter 10 CNS involvement in HLH (CNS-HLH)AnnaCarin Horne, Karin BeutelChapter 11 Genetics and Pathogenesis of Haemophagocytic LymphohistiocytosisGeneviève de Saint Basile1, Despina Moshous, Alain FischerChapter 12 Hemophagocytic Lymphohistiocytosis  Associated with Malignancies and with Epstein Barr VirusChapter 13 Macrophage Activation Syndrome in Rheumatic Diseases (MAS-HLH)Alexei A. Grom, AnnaCarin Horne, Fabrizio De BenedettiChapter 14 Treatment of Newly Diagnosed HLH and Refractory Disease Jan-Inge Henter, Rebecca A Marsh, Tatiana von Bahr GreenwoodChapter 15 Hematopoietic Cell Transplantation and Novel Therapies in Hemophagocytic LymphohistiocytosisK. Scott Baker, Michael B. JordanChapter 16 HLH in AdultsPaul La Rosée, Rafal MachowiczSection IV Rare Histiocytic Disorders: Non-Langerhans Cell HistocytosisChapter 17 Juvenile Xanthogranuloma and Related Non-LCH DisordersFrancesco Ceppi, Oussama AblaChapter 18 Erdheim-Chester Disease Eli L. Diamond, Benjamin H. DurhamChapter 19 Rosai-Dorfman DiseaseOussama Abla, Jennifer PicarsicChapter 20 Malignant HistiocytosesEric Jacobsen, Oussama Abla, Johannes Visser

Erscheint lt. Verlag 17.11.2017
Zusatzinfo XII, 392 p. 96 illus., 74 illus. in color.
Verlagsort Cham
Sprache englisch
Themenwelt Medizin / Pharmazie Allgemeines / Lexika
Medizin / Pharmazie Medizinische Fachgebiete Onkologie
Schlagworte Erdheim-Chester disease • hemophagocytic lymphohistiocytosis • JXG family • langerhans cell Histiocytosis • macrophage activation syndrome • Rosai-Dorfman disease
ISBN-10 3-319-59632-2 / 3319596322
ISBN-13 978-3-319-59632-7 / 9783319596327
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