Precision Molecular Pathology of Lung Cancer (eBook)

Philip T. Cagle, MDHouston Methodist HospitalDepartment of Pathology & Genomic Medicine6565 Fannin StHouston, TX 77030Timothy C. Allen, MDThe University of Texas Medical Branch Department of Pathology301 University BoulevardGalveston, TX 77555Mary Beth Beasley, MDMount Sinai HospitalDepartment of Pathology1468 Madison AvenueNew York, NY 10029Lucian R. Chirieac, MDBrigham And Women's HospitalDepartment of Pathology75 Francis St.Boston, MA 02115Sanja Dacic, MD, PhDUniversity of Pittsburgh Medical CenterDepartment of Pathology200 Lothrop St.Pittsburgh, PA 15213Alain C. Borczuk, MDWeill Cornell University Medical CenterDepartment of Pathology1300 York AvenueStarr-1000ANew York, NY 10065Keith M. Kerr, MDAberdeen University Medical SchoolAberdeen Royal InfirmaryDepartment of PathologyForesterhillAberdeen, ScotlandLynette Sholl, MDBrigham And Women's HospitalDepartment of Pathology75 Francis StBoston, MA 02115Bryce Portier, MDHouston Methodist HospitalDepartment of Pathology & Genomic Medicine6565 Fannin StHouston, TX 77030Eric Bernicker, MDHouston Methodist HospitalThoracic Medical Oncology6445 Main St, Floor 21Houston, TX 77030 

I. Background1. Precision Medicine of Lung Cancer: Introduction2. Lung Cancer Epidemiology and Demographics3. Genetic Susceptibility to Lung Cancer4. Lung Cancer Stem Cells5. The 2015 World Health Organization Classification of Lung Cancer: OverviewII. Testing Methods6. Preanalytic considerations7. Mutation testing of lung cancer biomarkers8. Translocation testing of lung cancer biomarkers9. Immunohistochemistry of lung cancer biomarkers10. Next Generation and Third Generation Sequencing of lung cancer biomarkersIII. Molecular Pathology of Specific Cell Types11. Mutations as Predictive Biomarkers for Adenocarcinoma12. Translocations as predictive Biomarkers for Adenocarcinoma13. Predictive Biomarkers for Squamous Cell Carcinoma14. Molecular Pathology of Small Cell Carcinoma15. Molecular Pathology of Uncommon Carcinomas16. Molecular Pathology of Lung Cancer Metastases17. Molecular Pathology of Precursor and Preinvasive LesionsIV. General and Emerging Fields in Molecular Pathology of Lung Cancer18. Prognostic biomarkers in lung cancer19. Biomarkers and Differing Therapy Modalities20. Immuno-oncology of Lung Cancer21. Liquid Biopsy.