Inflammation: Mechanisms and Treatment

Section I: Future Trends.- 1 The participation of mononucleur phagocytes in immune based inflammatory processes with special reference to their secretory responses.- Discussion.- 2 Future trends in mechanisms of cartilage destruction (Abstract).- Discussion.- 3 New developments in leukocyte Chemotaxis research: a survey.- Discussion.- 4 Future trends in free radical studies.- Discussion.- 5 Future trends in the immunopathology of rheumatoid arthritis.- Discussion.- 6 Future trends in anti-rheumatic drugs.- Discussion.- Section II: Review of Current Developments.- 7 A review of mechanism of action of steroid and non-steroid anti-inflammatory drugs.- Discussion.- 8 Review of immunotherapy in rheumatoid arthritis.- Discussion.- 9 Crystal deposition disease.- Discussion.- 10 T-cell dependent inflammatory responses.- Discussion.- 11 Arachidonic acid peroxidation in inflammation and its inhibition as a mechanism for anti-inflammatory activity.- 12 General Discussion.- Section III: Anti-Inflammatory and Anti-Rheumatic Agents.- 13 Review of pathogenesis of adjuvant arthritis and its relation to rheumatoid arthritis (Abstract).- 14 The anti-inflammatory activity of aspirin: the active metabolite.- 15 Indomethacin-sodium salicylate combination/RGH-6705 as a new possibility in the treatment of inflammation (Abstract).- 16 Tropesin: a new potential anti-rheumatic ester of indometacin.- 17 Development of an Arthus-like model of induced inflammation and its use in the anti-inflammatory characterization of orgotein (bovine Cu-Zn superoxide dismutase).- 18 The inhibition of macrophage accumulation in rats following injection of complete Freund's adjuvant (Abstract).- 19 Possible synergism between ovariectomy and oestradiol in preventing Freund's adjuvant arthritis in the rat.- 20 Anti-inflammatory actions of an immunomodulator: therafectin 1,2-O-isopropylidene-3-O-3?-(N', N'-dimethlyamino n-propyl)-D-gluco-furanose, HCl.- 21 Effects of benoxaprofen on macrophage function (Abstract).- 22 Some 'anti-arthritic' properties of an oversulphated glycosaminoglycan in degenerative joint disease.- 23 Anti-arthritic properties of ICI 55897 ('Clozic') (Abstract).- 24 Effect of ICI 55897 ('Clozic'), indomethacin and dexamethasone on collagenase and prostaglandin production by cultured rheumatoid synovial tissue (Abstract).- 25 The use of thymopoietin as an anti-inflammatory agent (Abstract).- 26 Production of hydrogen peroxide from neutrophils of rats (Abstract).- 27 Effects of D-penicillamine on granulation tissue and connective tissue of skin, aorta and bone in rats (Abstract).- 28 D-penicillamine in rheumatoid arthritis: fixed versus variable regimes.- 29 Effects of anti-inflammatory drugs on polymorphonuclear leukocyte aggregation (Abstract).- 30 Aggregation of rat polymorphonuclear leukocytes in vitro by chemotactic factors (Abstract).- 31 Preliminary report on the effect of a new derivative of acetyl salicylic acid on tissue-algogen component due to damaging stimulation of cutis.- Discussion.- Section IV: Pharmacological Mediators.- 32 Changes in the inflammatory mediator content in the colonic mucosae of immune colitides in guinea pigs (Abstract).- 33 Simultaneous continuous monitoring of blood volume and permeability in rabbit synovium: action of histamine.- 34 Leukotriene B: a biologically active release product of polymorphonuclear leukocytes.- 35 Arachidonic acid metabolism by lipoxygenase in leukocytes of different species and the chemokinetic activity of some products (Abstract).- 36 Aspirin-like drugs inhibit arachidonic acid metabolism via lipoxygenase and cyclo-oxygenase in rat neutrophils from carrageenin pleural exudates (Abstract).- 37 The possible role of divalent cations, microtubules and cyclic nucleotides in lymphokine induced macrophage aggregation.- 38 Inhibitory effect of benoxaprofen and BW 755C on rabbit PMN leukocyte lipoxygenase (Abstract).- 39 Mechanism of inhibition of prostaglandin biosynthesis by anti-inflammatory steroids.- 40 Selective control of formation of 1 and 2 series prostaglandins: a new concept in the regulation of inflammation and immunity.- 41 Human haptoglobin: an endogenous inhibitor of prostaglandin synthase.- 42 Release of thromboxane B2 and PGE2 by rabbit polymorphonuclear leukocytes (Abstract).- 43 Prostaglandin and thromboxane production by rat macrophages (Abstract).- 44 Specificity of glucocorticoid inhibition of synovial prostaglandin synthesis.- 45 Collagenase release from synovial fibroblasts: relationship to fatty acid release and prostaglandin synthesis.- 46 Observations on the influence of anti-oxidant compounds on prostaglandin biosynthesis (Abstract).- 47 Preliminary data on the influence of thyroid function on prostaglandin biosynthesis (Abstract).- Discussion.- Section V: Experimental Models of Inflammation and Chemotaxis.- 48 Effect of pharmacologic agents on macrophage accumulation.- 49 The histology of cotton pellet and polyvinyl sponge induced granulomas in rats (Abstract).- 50 A biochemical and morphological study of the cotton pellet granuloma in the rat: effects of dexamethasone and indomethacin (Abstract).- 51 Neutrophil interactions with particulate materials: an in vitro model for inflammatory arthritides.- 52 An in vitro mouse macrophage model for use in assessing the effects of anti-inflammatory drugs.- 53 Monosodium urate monohydrate stimulates release of lysosomal enzymes and prostaglandins from macrophages.- 54 Comparison between calcium pyrophosphate and monosodic urate induced inflammations of the palatal connective tissue.- 55 Intracellular killing of micro-organisms by phagocytic cells: the effect of extracellular stimuli (Abstract).- 56 In vivo studies on the influence of antigen induced joint inflammation on patellar hyaline articular cartilage.- 57 A stereological analysis of collagen phagocytosis in a model of chronic inflammation in rats (Abstract).- 58 Modification of Chemotaxis and peptide binding during pathophysiological state of polymorphonuclear leukocytes.- 59 Diverging effects of chemotactic serum peptides and synthetic f-Met-Leu-Phe on neutrophil locomotion and adhesion (Abstract).- 60 Correlation between aggregative and Chemotaxis inducing activities of five chemotactic peptides (Abstract).- 61 On the mechanism of human polymorphonuclear leukocyte deactivation of Chemotaxis by the synthetic peptide formyl-methiony-leucyl-phenylalanine.- 62 Dynamics of membranes in viable leukocytes associated with cellular recognition and biological memory in Chemotaxis and promotion of locomotion in chemokinesis (Abstract).- Discussion.- Section VI: Measurement of Human and Experimental Inflammation.- 63 Quantitiative assessment of experimentally induced arthritis in guinea pigs using microfocal radiography.- 64 Glutathione in erythrocytes: a parameter of change in disease activity and response to drugs in rheumatoid arthritis.- 65 Effect of drugs on serum copper and its correlation with other humoral factors in rheumatoid arthritis.- 66 The effect of therapeutic agents on serum copper levels and serum oxidase activities in the rat adjuvant model compared to analogous results from studies of rheumatoid arthritis in humans.- 67 Serum and synovial fluid ferritin in rheumatoid arthritis.- 68 Circulating and intra-articular immune complexes in rheumatoid arthritis: their relationship with disease activity.- 69 ?2-microglobulin, anti-?2-microglobulin activity and circulating immune complexes in rheumatoid arthritis: seric and synovial studies.- 70 Technetium-99m labelled leukocytes: preparation, animal studies, and potential application.- 71 Knee rheumatoid synovitis (KRS) successfully treated with intra-articular rifamyicin SV (Abstract).- 72 HLADR typing and rheumatoid arthritis (RA) (Abstract).- 73 Preliminary studies comparing 67Ga uptake with 99mTc uptake and clinical score in rheumatoid arthritis (Abstract).- Discussion.- Section VII: Immune Aspects.- 74 Macrophage activation by Listeria-specific T cell sub-populations (Abstract).- 75 Activation of mouse peritoneal macrophages and of the alternative pathway of the complement system by cartilage specific collagen type II.- 76 Interaction of macrophages and synthetic polyanions in the inflammatory response.- 77 Activation of complement by metal compounds that induce chronic granulomatous inflammation.- 78 Different susceptibilities to 4-hydroperoxycyclophosphamide of T cell sub-sets involved in delayed-type hypersensitivity of mice to sheep red blood cells.- 79 RES impairment in NZB/W mice.- 80 Rheumatoid immunoblasts and the effect of gold and cytotoxic drugs.- 81 Immunological and clinical effects of human placenta-eluted gammaglobulins (PEGG) in rheumatoid arthritis.- 82 Modification of antibody responses during non-specific acute inflammation (Abstract).- 83 Levamisole and thymopoietin pentapeptide (TP5) correction of E-rosette depression in man. In vitro and in vivo studies.- 84 Comparison between a curative and a preventive effect of an immunological therapy on an experimental gingivitis.- 85 A prospective study of 17 autoantibodies (AA) in 176 cases of rheumatoid arthritis (RA) treated with D-penicillamine (DP) (Abstract).- 86 Lymphokines, monokines, leukokines: large scale production, isolation and properties of leukocyte-derived cytotaxins, cytokinesins, cytotoxins and mitogens (Abstract).- Discussion.- Section VIII: Inflammation - General Aspects.- 87 Experimental protoporphyria in hairless mice: Photodermatitis.- 88 Experimental protoporphyria in hairless mice: photohaemolysis versus Photodermatitis.- 89 Morphological studies of inflammatory reactions: the relationships between the delayed-type hypersensitivity reaction and the Arthus reaction induced in the rat with ovalbumin.- 90 Regulatory mediators in Arthus reactions: demonstration of chemotactic factor inactivator and cell directed inhibitor activity.- 91 Regulatory mediators in Arthus reactions: lysosomal enzymes in biopsy and serum.- 92 Effect of flurbiprofen on prostaglandin synthesis (Abstract).- 93 Intrapleural injection of asbestos induces early sister chromatid exchanges increase in bone marrow cells (Abstract).- 94 The effect of an acute inflammatory process on the resistance to infection in mice.- 95 Interaction of inflammatory stimuli: diminished inflammatory response induced by cell accumulation at a distant site (Abstract).- 96 Anti-inflammation in spontaneously arising animal cancers.- 97 Effect of tumour growth on inflammatory macrophages.- 98 Effect of an acute inflammatory process on tumour development.- 99 Role of endogenous pyrogen in the rabbit febrile responses to muramyl dipeptide (Abstract).- Discussion.- Section IX: Lymphocytes.- 100 Comparative migration of guinea pig T and B lymphocytes from capillary tubes (Abstract).- 101 T lymphocyte sub-populations in rheumatoid arthritis.- 102 Enkephalins and the immune system (Abstract).- 103 Experimental inhibition of E-rosette forming cells by in vitro incubation with adenosine, theophylline and verapamil.- 104 Lymphocytes bearing Fc ? receptors in rheumatoid arthritis: binding properties of the Fc receptors detected by Facb rosettes and 'high avidity' EA rosettes.- 105 'L' lymphocytes, immune complexes and the amplification of human T lymphocyte proliferation.- 106 Influence of anti-inflammatory drugs on PHA-stimulated lyn. phocyte proliferation with variable numbers of macrophages.- 107 Influence of regional blood flow and inflammation on the localization of lymphoblasts in the small intestine of the mouse.- 108 Early lymphocyte activation and proliferative response induced by lectins: individual variations in man.- 109 Lymphocyte responsiveness in acute and convalescent infectious mononucleosis (Abstract).- 110 Quantitative measurement of human leukocyte aggregation as a possible correlation with cell mediated immunity.- Discussion.- Section X: Enzymes and Cell Secretion Products.- 111 Macrophages as origin of factor increasing monocytopoiesis (FIM) (Abstract).- 112 Phagocytosis and enzymatic activity of PGE1 treated rat peritoneal macrophages (Abstract).- 113 Alterations in bone marrow leukocyte ultrastructure and alkaline phosphatase activity accompanying a peripheral inflammatory response in the rat (Abstract).- 114 In vivo inhibition of PMN migration by antimacrophage serum.- 115 Macrophage involvement in chemotactic response.- 116 Determination of free lipid A and endotoxin (Abstract).- 117 Mycoplasmas stimulate mouse peritoneal macrophages to secrete lysosomal enzymes and to be cytotoxic.- 118 Influence of colchine derivatives on lysosomal enzyme release from polymorphonuclear leukocytes and intracellular levels of cAMP after phagocytosis of monsodium urate crystals.- 119 Biological and biochemical activities of in vitro differentiating murine bone marrow macrophages (Abstract).- 120 Effect of synovial tissue on the matrix of articular cartilage in organ culture (Abstract).- 121 Effect of irradiation and cell reconstitution on the macrophage mitogenic activity of exudate and inflammatory serum.- 122 Effect of chronic inflammatory exudate on cell morphology and cell functions (Abstract).- 123 Macrophages are activated by endocytosis of ?2-macro-globulin-protease complexes to produce neutral proteases.- 124 A mitogenic factor for macrophages present in rat serum (Abstract).- 125 Secretion of plasminogen activator by mouse peritoneal macrophages elicited by injection of a suspension of killed Streptococci.- Discussion.