Inflammation (eBook)

Jean-Marc Cavaillon is professor and Head of the Unit "Cytokines and Inflammation" at Institut Pasteur (Paris). He has been President of the "International Endotoxin and Innate Immunity Society". He is member of the Editorial Boards of few journals including Shock, Journal of Infectious Diseases, and International Journal of Inflammation, and has been Associate-Editor of "Cytokine" (2002-2009). Jean-Marc Cavaillon has an extensive expertise in innate immunity, particularly on cytokines, inflammation, bacterial endotoxins and other Toll-like receptors agonists, endotoxin tolerance, activation of monocytes/macrophages and neutrophils, altered immune status in sepsis and SIRS patients. He is the co-author of a book "Sepsis and non-infectious inflammation: from biology to critical care" (Wiley VCH, 2009) and the author of a book in French on cytokines (Masson, 1993 & 1996) . Jean-Marc Cavaillon has published 145 scientific articles, 77 reviews and 45 chapters in books. Mervyn Singer is Professor of Intensive Care Medicine at University College London. His primary research interests are sepsis and multi-organ failure, infection, shock and haemodynamic monitoring. Funding for these activities primarily comes from the Wellcome Trust, Medical Research Council and National Institute for Health Research. He developed an oesophageal Doppler haemodynamic monitor that is now in widespread use worldwide, the use of which has been shown in multiple studies to improve outcomes after major surgery and reduce length of stay. He has led on a number of important multi-centre trials in critical care. He has authored various papers and textbooks including the Oxford Handbook of Critical Care, now in its 3rd Edition, and is a Council member of the International Sepsis Forum. He was the first UK intensivist to be awarded Senior Investigator status by the National Institute for Health Research, and to be invited to give plenary lectures at the European and US Intensive Care Congresses.

Inflammation through the Ages: A Historical Perspective

PART I: INDUCERS AND SENSORS OF INFLAMMATION
Pathogen-associated Molecular Patterns
Damage-associated Molecular Patterns
Bacterial Toxins
Venoms
Hypoxia as an Inducer of Inflammation
Vaccine Adjuvants
Pattern Recognition Receptors

PART II: INFLAMMATORY CELLS
Monocytes and Macrophages
Neutrophils
Mast Cells: Master Drivers of Immune Responses against Pathogens
Dendritic Cells in Inflammatory Disease
Roles for NK Cells and ILC1 in Inflammation and Infection
Group 2 and Group 3 Innate Lymphoid Cells: New Actors in Immunity and Inflammation
Th9 Cells: From the Bench to the Bedside and Back Again
Th17 Cells
Platelets
Epithelial Cells
Inflammation: The Role of Endothelial Cells

PART III: INFLAMMATORY MEDIATORS
IL-1 Superfamily and Inflammasome
TNF Superfamily
Interleukin-17 A-E
IL-6 Superfamily
Type I and II Cytokine Superfamilies in Inflammatory Responses
Chemokines and Chemotaxis
Lipid Mediators in Inflammation
Free Radicals in Inflammation
Proteases
Psychiatric Disorders and Inflammation
Complement System
Heat Shock Proteins

PART IV: INFLAMMATION AND HOST RESPONSE
Inflammation and Coagulation
Fever: Mediators and Mechanisms
Pain
Inflammation, Hormones and Metabolism
Microenvironmental Regulation of Innate Immune Cell Function
Epigenetics of Inflammation

PART V: INFLAMMATION AND DISEASES
Allergy and Inflammation
Sepsis
Autoimmunity and Inflammation
Psoriasis and Other Skin Inflammatory Diseases
Rheumatoid Arthritis and Other Inflammatory Articular Diseases
Missing Heritability of Crohn's Disease and Implications for Therapeutic Targeting and Improved Care
Inflammation and Transplantation
Inflammatory Mechanisms in Chronic Obstructive Pulmonary Disease
Obesity: A Complex Disease with Immune Components
Inflammation and Type 2 Diabetes
Inflammation-Mediated Neurodegeneration: Models, Mechanisms, and Therapeutic Interventions for Neurodegenerative Diseases
Inflammation in Atherosclerosis
Acute Kidney Injury
Ischemia-Reperfusion Syndrome
Single Nucleotide Polymorphisms and Inflammation

PART VI: RESOLUTION OF INFLAMMATION AND TISSUE REPAIR
Pentraxins in the Orchestration of Defence and Tissue Repair During the Acute Phase Response
Anti-inflammatory Cytokines, Soluble Receptors, and Natural Antagonists
Regulatory T Cells
Leukocyte Reprogramming
Roles of Specialized Proresolving Lipid Mediators in Inflammation-Resolution and Tissue Repair
Glucocorticoids
The Neuroimmune Communicatome in Inflammation
The Inflammatory Response in Tissue Repair

PART VII: DETECTION AND TREATMENTS
Biomarkers in Inflammation
In Vivo Imaging of Inflammation
Novel Targets for Drug Development
Inflammation, Microbiota and Gut Reconditioning
Natural Products as Source of Anti-Inflammatory Drugs