Label-free and Multi-parametric Monitoring of Cell-based Assays with Substrate-embedded Sensors (eBook)
XXVI, 370 Seiten
Springer International Publishing (Verlag)
978-3-319-45384-2 (ISBN)
Maximilian Oberleitner was born in 1983 in Bavaria, Germany and graduated from the University of Regensburg with a Diploma in Chemistry in 2008. Based on this doctoral thesis 'Label-free and Multi-parametric Monitoring of Cell-based Assays with Substrate-embedded Sensors' he obtained his PhD in Analytical Chemistry in 2016 in the Institute of Analytical Chemistry, Chemo- and Biosensors at the University of Regensburg under the supervision of Prof. Dr. Joachim Wegener. His research work was focused on the development and improvement of substrate-integrated sensors for the analysis of living cells. These sensors enable the monitoring of cell-substrate interactions and the real-time analysis of assays with adherently grown cells in a non-invasive, label-free and - by combinations of the different types of sensors - even in a multi-parametric manner. Since 2015 he works at a global healthcare company in Austria. As project leader in the quality unit he is responsible for stability studies and quality evaluations of antibiotics.
Maximilian Oberleitner was born in 1983 in Bavaria, Germany and graduated from the University of Regensburg with a Diploma in Chemistry in 2008. Based on this doctoral thesis “Label-free and Multi-parametric Monitoring of Cell-based Assays with Substrate-embedded Sensors” he obtained his PhD in Analytical Chemistry in 2016 in the Institute of Analytical Chemistry, Chemo- and Biosensors at the University of Regensburg under the supervision of Prof. Dr. Joachim Wegener. His research work was focused on the development and improvement of substrate-integrated sensors for the analysis of living cells. These sensors enable the monitoring of cell-substrate interactions and the real-time analysis of assays with adherently grown cells in a non-invasive, label-free and – by combinations of the different types of sensors – even in a multi-parametric manner. Since 2015 he works at a global healthcare company in Austria. As project leader in the quality unit he is responsible for stability studies and quality evaluations of antibiotics.
Introduction.- Objectives.- Methods & Instrumentation.- MQCM: Multiple Cytomechanic Sensing.- QCM-ECIS: Combined Viscoelastic and Dielectric Sensing of Cells.- QCM-OCS: Optochemical Sensing of Temperature and pO2 in the Cell Surface Junction.- Summary.- Appendix.
Erscheint lt. Verlag | 26.9.2017 |
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Reihe/Serie | Springer Theses | Springer Theses |
Zusatzinfo | XXVI, 370 p. 138 illus., 122 illus. in color. |
Verlagsort | Cham |
Sprache | englisch |
Themenwelt | Studium ► 1. Studienabschnitt (Vorklinik) ► Biochemie / Molekularbiologie |
Naturwissenschaften ► Biologie | |
Naturwissenschaften ► Chemie | |
Schlagworte | Biological recognition unit • Cell-based assays • Cell Culture • Confocal laser scanning microscopy • Cytomechanic sensing • Dynamic cell response • Electric cell-substrate impedance sensing • Fluorescence lifetime imaging • Impedance spectroscopy • Label-free high-content sensing • Mulitparametric whole-cell biosensing • Optical temperature and oxygen imaging • Quartz crystal microbalance |
ISBN-10 | 3-319-45384-X / 331945384X |
ISBN-13 | 978-3-319-45384-2 / 9783319453842 |
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