Hematology-Oncology Clinical Questions

Julie H. Rowe, MD; Anneliese O. Gonzalez, MD; SyedH. Jafri, MBBS.; Putao Chen, MD; Zeyad Kanaan, MD; and Robert J. Amato, DO, Adan Rios, MD, Hazem El-Osta, MD are affiliated with The University of Texas Health Scienceat Houston, McGovern Medical School.

Table of Contents

 



1. CHEMOTHERAPY AGENTS –WILL INCLUDE A SUMMARY OF EACH TYPE BEFORE CLINICAL QUESTIONS



a. Cytotoxic

b. Targeted Agents

c. Hormonal Agents

d. Immunotherapy



2. RADIATION THERAPY



3. MOST COMMON HEME QUESTIONS

a. Anemia

b. Thrombocytopenia

c. Thrombosis

d. Transfusion reactions



4. SCREENING

a. Breast cancer

b. Cervical

c. Colon Cancer

d. Prostate

e. Lung Cancer



5. BREAST CANCER

a. Non-invasive

b. Invasive

c. Inflammatory breast cancer

d. Phyllodes

e. Paget’s



6. HEAD AND NECK



7. THYROID CARCINOMAS



8. GI CANCER

a. Esophagus

b. Gastric/GEJ

c. Colon

d. Rectal

e. Anus

f. Pancreas

g. Cholangiocarcinoma

h. Hepatocellular Carcinoma

i. Neuroendocrine tumors



9. GU CANCER

a. Bladder

b. Kidney

c. Prostate

d. Testicular



10. GYNECOLOGICAL MALIGNANCIES

a. Cervical

b. Endometrial

c. Ovarian

d. Uterine



11. MELANOMAS



12. THORACIC

a. Small cell lung cancer

b. Non-small cell lung cancer



13. SARCOMAS



14. OCCULT PRIMARY



15. BASICS OF PATHOLOGY AND HEMATOLOGY

a. Bone Marrow, Flow Cytometry, Cytogenetics, Molecular testing.

b. Solid tumor pathology basics



16. BASICS OF BONE MARROW TRANSPLANTATION

a. Types (Allo, Auto)

b. Indications



17. LYMPHOMAS

a. Hodgkin’s Lymphoma

i. Classical HL

ii. Nodular lymphocyte-predominant HL

b. Non-Hodgkin’s Lymphoma

i. B-cell NHL

a) Diffuse large B-cell Lymphoma (DLBCL)

b) Follicular Lymphoma

c) Mantle Cell Lymphoma (MCL)

d) Small Lymphocytic Lymphoma (SLL)

e) Primary CNS Lymphoma

f) Primary Mediastinal Lymphoma (PML)

g) Burkitt Lymphoma (BL)

h) Primary Effusion Lymphoma

i) Double-hit Lymphoma

j) Primary Effusion Lymphoma (PEL)

ii. T-Cell NHL

a) Peripheral T-cell Lymphoma (PTCL)

b) Primary Cutaneous T-cell Lymphoma

c) Anaplastic Large Cell Lymphoma (ALCL)

d) Post-Transplant Lymphoproliferative



18. LEUKEMIAS

a) Acute Leukemias

i. Acute Myeloid Leukemia (AML)

ii. APL

i. Acute Lymphoblastic Leukemia (ALL)

b) Chronic Leukemias:

i. Chronic Myeloid Leukemia (CML)

ii. Chronic Lymphocytic Leukemia (CLL)

iii. Hairy Cell Leukemia



19. PLASMA CELL DISORDERS:

a. Monoclonal Gammopathy of Undetermined Significance (MGUS)

b. Multiple Myeloma (MM)

c. Lymphoplasmacyctic Lymphoma (including Waldenstrom’s Macroglobulinemia)

d. Solitary Plasmacytoma

e. AL Amyloidosis

f. POEMS Syndrome



20. MYELOPROLIFERATIVE NEOPLASMS

a. Polycythemia Vera (PV)

b. Essential Thrombocythemia (ET)

c. Primary Myelofibrosis (PMF)

d. Systemic Mastocytosis (SM)



21. MYELODYSPLASTIC SYNDROMES



22. GUIDELINES FOR SUPPORTIVE CARE

a. Management of Side Effects of Chemotherapy

i. Myelosuppression

ii. Nausea

iii. Vomiting

iv. Diarrhea

v. Mucositis

vi. Anorexia, weight loss

b. Management of Cancer-related pain

c. Management of Cachexia



23. ONCOLOGIC EMERGENCIES

a. Neutropenic Fever

b. Spinal Cord Compression

c. Tumor Lysis Syndrome

d. Superior vena cava syndrome

e. Hypercalcemia of malignancy

f. Hyperleukocytosis and leukostasis



24. GENETIC AND FAMILIAL ASSESSMENT
FOR FAMILIAL CANCER SYNDROMES



25. END OF LIFE