Stem Cells in the Lung

Ivan Bertoncello, MSc, PhD is an Honorary Principle Research Fellow and Associate Professor in the Department of Pharmacology and Therapeutics; and a member of the executive of the Lung Health Research Centre, at the University of Melbourne, Victoria, Australia. He has previously held appointments as Head of the Adult Lung Stem Cell Laboratory at the Australian Stem Cell Centre at Monash University; and Head of the Lung Regeneration Laboratory in the Department of Pharmacology and Therapeutics at the University of Melbourne. His international reputation in stem cell research was originally built on pioneering studies analysing the organisation and regulation of bone marrow stem and progenitor cells. His laboratory employed similar methods to analyse endogenous adult lung stem and progenitor cells in order to understand how regenerative cells in the adult lung are organised, and how they can be harnessed to treat lung disease or repair the injured lung.

Part 1. Fetal Lung Development.- The Regulation of Branching Morphogenesis in the Developing Lung.- Epithelial-Mesenchymal Crosstalk in Lung Development.- Lung Vasculogenesis and Angiogenesis.- Neural Regulation of Lung Development.- Fetal and Neonatal Origins of Lung Disease.- Part 2. Adult Lung Stem and Progenitor Cells.- Stem and Progenitor Cells of the Trachea and Proximal Airways.- Stem and Progenitor Cells of the Distal Bronchiolar Airways.- Regenerative Cells in the Ageing Lung.- Part 3. Regulation of Lung Regeneration and Repair.- Stromal Regulation of Lung Regeneration and Repair.- Immunomodulatory Regulation Of Lung Regeneration and Repair.- Extracellular Matrix Specification of Regenerative Cells in the Adult Lung.- Role of Mechanical Stress in Lung Repair and Regeneration.- Part 4. Cellular Therapies for Lung Disease.- Cellular Origins of Fibrotic Lung Diseases.- Mesenchymal Stromal Cell Based Therapies for Lung Disease.- Lung Vascular Regeneration and Repair.- Directed Differentiation of Human Pluripotent Stem Cells into Lung and Airway Epithelial Cells.- Part 5. Bioengineering the Lung.- Regenerating the Respiratory Tract.- Acellular Lung Scaffolds in Lung Bioengineering.- Part 6. Afterword.-Prospects and Challenges in Lung Regenerative Medicine.