Studies on Experimental Toxicology and Pharmacology

Stephen M. Roberts, Ph.D. is Director of the Center for Environmental & Human Toxicology at the University of Florida, and is a Professor with joint appointments in the College of Veterinary Medicine, College of Medicine, and the College of Public Health and Health Professions. He received his Ph.D. from the University of Utah College of Medicine, and has developed an active research career focusing on mechanisms of toxicity of drugs and chemicals with funding from the National Institutes of Health, the U.S. Environmental Protection Agency, the Department of Defense, and private industry. He has served on a federal scientific advisory committees dealing with matters related to toxicology for the U.S. Department of Health and Human Services, the Food and Drug Administration, and the U.S. Environmental Protection Agency.

Part I. Toxicological Mechanisms and Evaluation of Oxidative Stress .- A historical perspective on oxidative stress and intracellular redox control .- An overview of free radicals as causes and consequences of toxicity.- Oxidants, radicals, free radicals, and other bad stuff in mechanisms of toxicity.- Lipid oxidation.- Protein oxidation and toxicology.- Oxidative stress and DNA damage association with carcinogenesis: A truth or a myth?.- Glutathione and thiols .- Reactive oxygen species as initiators and mediators of cellular signaling processes.- Role of oxidative stress in the process of carcinogenesis.- Part II. Agents that produce toxicity - mechanisms and therapeutic interventions .- Isolation of murine adult bone marrow and fetal liver cells for mechanistic assessment of hematotoxicity caused by organic solvents.- Oxidative stress and ethanol toxicity.- Pharmaceutical agents.- Insecticides and herbicides .- Health effects of indoor air pollution due to cooking with biomass fuel.- Outdoor pollutants.- Oxidative Stress and the Inorganic Carcinogens.- UV-induced signaling: Role of reactive oxygen species.- Nanomaterials.- Chemical warfare agents.- Part III. Special topics.- On the biochemistry of antioxidants - current aspects .-Prevention of age-related diseases - Effects of antioxidant supplements.- The neural progenitor cell (NPC) niche in the adult brain provides a target for neurotoxicity - a potential Adverse Outcome Pathway for ROS-induced NPC dysfunction with higher sensitivity during aging..- Oxygen toxicity: From cough to convulsion.- Oxidative stress in reproductive toxicology.- Toxicogenomics-based assessment of xenobiotic-induced oxidative stress.- Aquatic and marine biology.