IgM and Its Receptors and Binding Proteins -

IgM and Its Receptors and Binding Proteins

Buch | Hardcover
IX, 117 Seiten
2017 | 1st ed. 2017
Springer International Publishing (Verlag)
978-3-319-64524-7 (ISBN)
149,79 inkl. MwSt
This volume reviews the current state of research on the IgM antibody and its multiple receptors and binding proteins. Interactions of the IgM ligands with these molecules are important for protection against infections as a first line of defense, as well as for regulation of immune responses to pathogens and self-antigens. The book includes up-to-date information on: (i) the phylogeny of three IgM-binding receptors [polymeric Ig receptor (pIgR), Fc receptor for both IgA and IgM (Fc /µR), and Fc receptor for IgM only (FcµR)]; (ii) the lymphocyte-restricted distribution and unique ligand-binding activity of FcµR; (iii) the definition and potential function of Fc receptor-like molecule A (FCRLA) as a resident endoplasmic reticulum protein that binds IgM, but also IgG and IgA; (iv) IgM antibody-mediated enhancement of humoral immune responses, highlighting the importance of complement and its receptors, (v) the numerous important roles of IgM natural antibodies in regulation of inflammation. It is an invaluable resource for researchers and clinicians alike.

Hiromi Kubagawa, MD, is presently Guest Senior Scientist at Deutsches Rheuma-Forschungszentrum, Berlin, Germany Peter D. Burrows, PhD, is a professor at Dept. of Microbiology, University of Alabama at Birmingham, AL, USA

The appearance and diversification of receptors for IgM during vertebrate evolution..- Authentic IgM Fc Receptor (FcmiR).- FCRLA - A resident endoplasmic reticulum protein that associates with multiple immunoglobulin isotypes in B lineage cells.- Specific IgM and regulation of antibody responses.- Role of Natural IgM autoantibodies (IgM- NAA) and IgM anti-leucocyte antibodies (IgM-ALA) in regulating inflammation.

Erscheinungsdatum
Reihe/Serie Current Topics in Microbiology and Immunology
Zusatzinfo IX, 117 p. 30 illus., 15 illus. in color.
Verlagsort Cham
Sprache englisch
Maße 155 x 235 mm
Gewicht 320 g
Themenwelt Medizinische Fachgebiete Innere Medizin Rheumatologie
Studium Querschnittsbereiche Infektiologie / Immunologie
Schlagworte Antibody response • Biomedical and Life Sciences • Fc receptor • Fc-receptor evolution • FCRLA • Fcα/µR • Fc /µR • Fc/µR • FcµR • iga • immunology • Infectious & contagious diseases • Infectious & contagious diseases • Infectious Diseases • Medical Research • natural antibodies • pIgR • rheumatology
ISBN-10 3-319-64524-2 / 3319645242
ISBN-13 978-3-319-64524-7 / 9783319645247
Zustand Neuware
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