Copper Amine Oxidases

Giovanni Floris, Bruno Mondovi

History. Nomenclature and Potential Functions of Copper Amine Oxidases. Cofactors of Amine Oxidases: Copper Ion and Its Substitution and the 2, 4, 5-Trihydroxylphenylalanine Quinone. Copper Amine Oxidases from Plants. Soluble Copper Amine Oxidases from Mammals. Membrane-Bound Copper Amine Oxidases. Copper Amine Oxidase Genes. Mechanism of TPQ Biogenesis in Prokaryotic Copper Amine Oxidase. Copper Amine Oxidase Crystal Structures. Plasma Amine Oxidases in Various Clinical Conditions and in Apoptosis. Copper Amine Oxidases in Intestine Diseases. Copper Amine Oxidases in Adipose Tissue-Related Disorders. Copper Amine Oxidases in Adhesion Molecules in Renal Pathology and in Alzheimer’s Disease and VAP-1 in Leukocyte Migration. Inhibitors of Copper Amine Oxidases: Past, Present, and Future. Pharmacological Applications of Copper Amine Oxidases. Copper Amine Oxidases as Antioxidant and Cardioprotective Agents. Biotechnological Aspects of Copper Amine Oxidases. Concluding Remarks. References.