Handbook of Experimental Pharmacology / Drug Toxicity in Embryonic Development I

The prevention of birth defects in the human populations caused by exogenous chemicals is a goal of both primary care providers, drug developers, experimental teratologists, and risk assessors. This two-volume work provides a state-of- the-science assessment of how embryos accomplish the feat of morphogenesis at the molecular and cellular level, the key biochemical processes that drive morphogenesis and which are thus at risk to disruption, and the mechanisms of action by which known human teratogens exert their unwanted effects. These volumes provide the first comprehensive compilation of material focused on the understanding of the mechanism of action of chemicals which cause birth defects. It will prove a valuable reference work for clinicians, health councilors, teratologists, developmental biologists and risk assessors.