Encyclopedia of Cardiovascular Research and Medicine

Douglas B. Sawyer specializes in basic and translational research and is focused on mechanisms by which the heart maintains cardiac function and recovers after injury. Formerly Chief of Cardiology at Vanderbilt University, USA, Dr Sawyer has more recently taken up a position at Maine Medical Center, where he is Chief of Cardiac Services and Physician Leader of the Cardiovascular Service Line. His clinical interests include Cardiovascular Disease, Heart Failure, Clinical and Translational Research. Dr Sawyer is a Fellow of the American College of Cardiology, was elected to the Association of University Cardiologists in 2011 and also elected to American Society for Clinical Investigation. Vasan is a noninvasive cardiologist with specialization in cardiovascular epidemiology, and a senior investigator at the Framingham Heart Study. He is the co-director of the echocardiography and vascular testing laboratory at the Framingham Heart Study and he directs its fellowship training program. His epidemiological research has focused on 4 inter-related areas: a. the epidemiology of congestive heart failure, including identifying risk factors for the disease, characterizing the subgroups with diastolic heart failure, asymptomatic LV systolic and diastolic dysfunction, and evaluating the role of LV remodeling; b. population-based vascular testing and echocardiography, including identifying biological, environmental, and genetic determinants (correlates) of cardiac structure and function; normative standards; detailed assessment of biomarkers of the process of LV remodeling; c. epidemiology of high blood pressure, including characterizing the lifetime risk, rates of progression and risks associated with various degrees of elevation; and, d. exercise physiology, and exercise test responses in asymptomatic individuals and prognostic information; relations to endothelial function.

List of Sections Basic cardiovascular anatomy, physiology, pathology and pharmacology Basic vascular biology Molecular biology and genetics/genomics in cardiovascular medicine Cardiovascular epidemiology and preventive cardiology Evaluative and treatment of cardiovascular disease, and clinical research methods Atherosclerotic cardiovascular disease Heart failure and cardiomyopathies Cardiac electrophysiology, arrhythmias and sudden death Diseases of pericardium, great vessels, pulmonary circulation and miscellaneous cardiovascular disorders Heart disease in special populations and cardiac involvement in systemic diseases