Developmental and Reproductive Toxicology -

Developmental and Reproductive Toxicology

Ali S. Faqi (Herausgeber)

Buch | Hardcover
314 Seiten
2017 | 1st ed. 2017
Humana Press Inc. (Verlag)
978-1-4939-7206-7 (ISBN)
160,49 inkl. MwSt
This meticulous volume covers metabolism and drug-drug interactions during pregnancy, critical periods of developmental toxicology, in vivo and alternative methods to assess potential developmental toxicity for drugs and chemicals, and effects of chemicals on testes and mammary glands. Evaluation of developmental and reproductive toxicology endpoints is an integral part of the safety assessment process for compounds with potential use in women of childbearing age or females that might be exposed during pregnancy as well as men of reproductive potential. The in vivo assessments included here are guideline-driven and are required for submissions for product approval. Written for the Methods in Pharmacology and Toxicology series, this collection includes the kind of detailed implementation advice necessary for success in the lab. 
Authoritative and practical, Developmental and Reproductive Toxicology is an ideal resource for researchers workingin this vital field of study.

Metabolism and Drug-Drug Interaction in Pregnant Mother/Placenta/Fetus.- Critical Periods of Development in Teratology.- Nonclinical Safety Assessment of Developmental and Reproductive Toxicology: Considerations for Conducting Fertility, Embryo-Fetal Development, and Pre- and Postnatal Developmental Toxicology Studies.- A Developmental and Reproductive Toxicology Program for Chemical Registration.- The Influence of Environmental Contaminants and Lifestyle on Testicular Damage and Male Fertility.- Effects of Chemicals on Mammary Gland Development.- Alternative Methods Used to Assess Potential Embryo-Fetal Developmental Risk of Pharmaceuticals.- Using the Alternative Model C. elegans in Reproductive and Developmental Toxicology Studies.- High-Throughput Screens for Embryonic Stem Cells: Stress-Forced Potency-Stemness Loss Enables Toxicological Assays.

Erscheinungsdatum
Reihe/Serie Methods in Pharmacology and Toxicology
Zusatzinfo 17 Illustrations, color; 7 Illustrations, black and white; XII, 314 p. 24 illus., 17 illus. in color.
Verlagsort Totowa, NJ
Sprache englisch
Maße 178 x 254 mm
Themenwelt Medizin / Pharmazie Medizinische Fachgebiete Pharmakologie / Pharmakotherapie
Medizin / Pharmazie Pharmazie
Schlagworte Animal Models • DART research • Drug-drug Interactions • Maternal environment • Pharmaceutical risk • Teratology
ISBN-10 1-4939-7206-5 / 1493972065
ISBN-13 978-1-4939-7206-7 / 9781493972067
Zustand Neuware
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