Molecular Oncology: Underlying Mechanisms and Translational Advancements (eBook)

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2017 | 1st ed. 2017
X, 302 Seiten
Springer International Publishing (Verlag)
978-3-319-53082-6 (ISBN)

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Cancer is a multifaceted and genomically complex disease and data obtained through high throughput technologies has provided near complete resolution of the landscape of how genomic, genetic and epigenetic mutations in cancerous cells effectively influence homeostasis of signaling networks within these cells, between cancerous cells, tumor microenvironment and at the organ level. Increasingly sophisticated information has helped us in developing a better understanding of the underlying mechanisms of cancer, and it is now known that intra-tumor genetic heterogeneity, cellular plasticity, dysregulation of spatio-temporally controlled signaling cascades, and loss of apoptosis are contributory in cancer development, progression and the development of resistance against different therapeutics. It is becoming progressively more understandable that earlier detection of pre-existing or emerging resistance against different therapeutics may prove to be helpful in personalizing the use of targeted cancer therapy. 

Despite the fact that there is a continuously increasing list of books, being guest edited by researchers, books on the subject are often composed of invited reviews without proper sequence and continuity and designed for a particular readership. This book progressively shifts and guides the readers from basic underlying mechanisms to translational approaches to treat cancer.



Ammad Ahmad Farooqi is currently a Senior Scientist at the Institute of Biomedical and Genetic Engineering (IBGE), in Islamabad, Pakistan. His area of research is tightly focused on cancer genetics and therapeutics.

Professor Muhammad Ismail has a Ph.D. in Biotechnology and is currently the Director of the Institute of Biomedical and Genetic Engineering (IBGE), in Islamabad. His main focus of research is Cancer Genetics and Therapeutics, Nanomedicine and Pharmacogenomics.

Ammad Ahmad Farooqi is currently a Senior Scientist at the Institute of Biomedical and Genetic Engineering (IBGE), in Islamabad, Pakistan. His area of research is tightly focused on cancer genetics and therapeutics.Professor Muhammad Ismail has a Ph.D. in Biotechnology and is currently the Director of the Institute of Biomedical and Genetic Engineering (IBGE), in Islamabad. His main focus of research is Cancer Genetics and Therapeutics, Nanomedicine and Pharmacogenomics.

Chapter 1: Microtubule targeting agents in cancer therapy: Elucidating the underlying molecular mechanismsChapter 2: Adenosine signaling pathways as potential therapeutic targets in cancer diseaseChapter 3: Anticancer activities of Hippophae rhamnoides: Journey from Benchtop to the BedsideChapter 4: Emerging role of ncRNAs in cancer biology: techniques for diagnostic monitoring and potential ncRNA-based therapies.Chapter 5: Clinical and translational research on the pathophysiology of several ocular tumors typesChapter 6: Exosomes and cancer: from diagnosis to therapyChapter 7: Blood-based Cancer Detection: Towards Solving Diagnostic PuzzleChapter 8: Non-coding RNAs, Critical Therapy Targets against CancerChapter 9: Detection of Virus-caused Cancer in Publicly Available Next Generation Sequencing DataChapter 10: TRAIL mediated signaling in prostate cancer:Index

Erscheint lt. Verlag 29.3.2017
Zusatzinfo X, 302 p. 27 illus., 24 illus. in color.
Verlagsort Cham
Sprache englisch
Themenwelt Medizin / Pharmazie Studium
Schlagworte Adenosine signaling pathways • Blood-based cancer detection • Cancer Therapy • exosomes • Microtubule targeting agents • Non-coding RNA • Oncology • Virus caused cancer
ISBN-10 3-319-53082-8 / 3319530828
ISBN-13 978-3-319-53082-6 / 9783319530826
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