Megaloblastic Anaemia

Morphology, biology and biochemistry of cobalamin and folate-deficient bone marrow cells; DNA damage in folate deficiency; biochemical basis of the neuropathy in cobalamin deficiency; transcobalamin II and the membrane receptor for the transcobalamin II - cobalamin complex; gastric intrinsic factor and its receptor; metabolite assays in cobalamin and folate deficiency; inborn errors of cobalamin metabolism and their management; congenital errors of folate metabolism; effects of folate deficiency on embryonic development; malabsorption of food cobalamin; neurological complications of acquired cobalamin deficiency: clinical aspects; cobalamin and folate deficiency in the elderly.