Disorders of Bone and Mineral Metabolism

Using basic and clinical research, this text provides in-depth coverage of the physiology, pathophysiology, clinical manifestations, diagnosis and management of a wide range of disturbances in bone and mineral metabolism.

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This important volume examines the pathophysiology, clinical characteristics, diagnosis, and management of bone disorders and disturbances in mineral metabolism. More than 50 leading specialist in pertinent clinical and research areas - including endocrinology, orthopedics, nephrology, urology, physiology, pathology, biochemistry, and molecular biology - integrate fundamental scientific principles with cogent clinical observations. Their objective is to establish a sytematic approach to the timely diagnosis and optimal management of these frequently complex disorders. The text is supplemented by extensive, bibliographic references and complemented by more than 500 illustrations - including nearly 20 full-colour illustrations of bone biopsy findings in the major metabolic skeletal disorders. Introductory reviews of normal mineral metabolism and bone structure and biology lay the groundwork for the clinically oriented discussions that follow. The book then describes laboratory and radiographic methods (including bone scanning) for diagnosis of clinical mineral disorders and offers definitive guidance on the indications for bone biopsy and the evaluation of biopsy specimens.
The remainder of the book covers the entire spectrum of inherited and acquired derangements of serum mineral levels, disorders of stone formation, and bone disorders, including those related to cancer, endocrine disturbances, nutritional disorders, and renal, gastrointestinal and hepatic disease.