Phosphodiesterases: CNS Functions and Diseases

Dr. Han-Ting Zhang received his M.D. from Southern Medical University (formerly the First Military Medical University) in Guangzhou and M.S. and Ph.D. of Pharmacology from Beijing Institute of Pharmacology & Toxicology, the Military Academy of Medical Sciences, China in 1995. He worked as a postdoctoral fellow at Louisiana State University Health Sciences Center in 1998 and then at University of Tennessee Health Science Center in 2000. In 2005 Dr. Zhang joined the Departments of Behavioral Medicine & Psychiatry and Physiology & Pharmacology as a faculty at West Virginia University School of Medicine, Morgantown, WV, USA. He has been a tenured Associate Professor there since 2012. Dr. Zhang is also a "Taishan Scholars" Overseas Distinguished Expert and Professor of Pharmacology at Taishan Medical University (adjunct), China.

Part I. PDEs and Signaling, Circuitry, and Implications of CNS Functions and Disorders.- 1. Phosphodiesterase Diversity and Signal Processing within cAMP Signaling Networks.- 2. Current Understanding of PDE10A in the Modulation of Basal Ganglia Circuitry.- 3. Interaction of Cdk5 and cAMP/PKA Signaling in the Mediation of Neuropsychiatric and Neurodegenerative Diseases.- 4. The PDE4 cAMP-specific Phosphodiesterases: Targets for Drugs with Antidepressant and Memory-enhancing Action.- 5. Phosphodiesterase-4B as a Therapeutic Target for Cognitive Impairment and Obesity-related Metabolic Diseases.- Part II. PDEs in Cognition of Aging and Alzheimer's Disease.- 6. From age-related Cognitive Decline to Alzheimer's Disease: A Translational Overview of the Potential role for Phosphodiesterases.- 7. The Past, Present, and Future of Phosphodiesterase-4 Modulation for age-induced Memory Loss.- 8. A Role for Phosphodiesterase 11A (PDE11A) in the Formation of Social Memories and the Stabilization of Mood.- 9. Role of PDE9 in Cognition.- Part III. PDEs in Parkinson's and Huntington's Diseases.- 10. Regulation of Striatal Neuron Activity by Cyclic Nucleotide Signaling and Phosphodiesterase Inhibition: Implications for the Treatment of Parkinson's Disease.- 11. Role of Phosphodiesterases in Huntington's Disease.- Part IV. PDEs and Psychiatric Disorders.- 12. The role of Phosphodiesterase-2 in Psychiatric and Neurodegenerative Disorders.- 13. Phosphodiesterase 1: A Unique Drug Target for Degenerative Diseases and Cognitive Dysfunction.- 14. PDE Inhibitors for the Treatment of Schizophrenia.- Part V. PDEs and Others.- 15. Targeting Phosphodiesterases in Pharmacotherapy for Substance Dependence.- 16. Genetic Understanding of Stroke Treatment: Potential role for Phosphodiesterase Inhibitors.- 17. A unique sub-pocket for Improvement of Selectivity of Phosphodiesterase Inhibitors in CNS.