Histamine and Histamine Receptors in Health and Disease

Part 1: New Analytical tools.- Histamine and histamine receptors: State of the art.- Mass-spectrometric methods for the detection of histamine and histamine metabolites.- Fluorescent ligands and radioligands for the analysis of histamine receptors.- Molecular analysis of histamine receptors: Structural analysis of the histamine H₁-receptor.- Molecular modelling approaches for the analysis of histamine receptors.- Cellular analysis of histamine receptors: Histamine release from human mast cells and basophils.- Histamine H₂-receptor in blood cells: A suitable target for the treatment of acute myeloid leukemia.- Histamine H₁-receptor-regulated gene expression and drug action of antihistamines.- Histamine metabolism and transport: Analysis of the role of histamine and genetically engineered mice in a human disease model.- Histamine clearance through polyspecific transporters in the brain.- Histamine decarboxylase deficiency as a cause for Tourette syndrome.- Histamine food poisoning.- Integrative role of histamine in major organ systems: Pharmacological implications: Regulation of the cardiovascular system by histamine.- Regulation of eating behavior by histamine.- Role of the histamine H₃-receptor in the CNS.- Role of the histamine H₄-receptor in bronchial asthma.- The histamine H₄-receptor in pruritic skin disease.- Histamine in allergy and antihistamines.