Epigenetics in Health and Disease (Paperback)

Igor Kovalchuk, Ph.D., MD, is Professor and Board of Governors Research Chair at the Department of Biological Sciences, University of Lethbridge (Alberta, Canada). He edits Frontiers in Plant Microbe Interaction, Frontiers in Epigenomics, and other journals. As principal investigator in the university’s Plant Biotechnology laboratory, he studies genetic and epigenetic regulation of plant response to stress, including the transgenerational effects of stress and microevolution of plant stress tolerance/resistance. Olga Kovalchuk, Ph.D., MD is Professor and Board of Governors Research Chair and CIHR Chair in Gender and Health at the University of Lethbridge and a member of the editorial boards of Mutation Research--Fundamental and Molecular Mechanisms of Mutagenesis and Environmental and Molecular Mutagenesis. She researches the role of epigenetic dysregulation in carcinogenesis; epigenetic regulation of cancer treatment responses; radiation epigenetics and role of epigenetic changes in genome stability and carcinogenesis; radiation-induced oncogenic signaling; and radiation-induced DNA damage, repair, and recombination.

Chapter 1   Historical Perspective     1
Chapter 2   Chromatin Dynamics and Chromatin Remodeling in Animals     19
Chapter 3   Chromatin Dynamics and Chromatin Remodeling in Plants     49
Chapter 4   DNA Methylation as Epigenetic Mechanism     75
Chapter 5   Histone Modifications and Their Role in Epigenetic Regulation     119
Chapter 6   Realm of Non-Coding RNAs--From Bacteria to Human     147
Chapter 7   Non-Coding RNAs Involved in Epigenetic Processes--A General Overview     177
Chapter 8   Non-Coding RNAs Across the Kingdoms--Bacteria and Archaea     203
Chapter 9   Non-Coding RNAs Across the Kingdoms--Protista and Fungi     223
Chapter 10  Non-Coding RNAs Across the Kingdoms--Animals     267
Chapter 11  Non-Coding RNAs Across the Kingdoms--Plants     297
Chapter 12  Non-Coding RNAs--Comparison of Biogenesis in Plants and Animals     327
Chapter 13  Paramutation, Transactivation, Transvection, and Cosuppression--Silencing of Homologous Sequences     343
Chapter 14  Bacterial Adaptive Immunity--Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)     385
Chapter 15  Gene Silencing--Ancient Immune Response and a Versatile Mechanism of Control over the Fate of Foreign Nucleic Acids     409
Chapter 16  Epigenetics of Germline and Epigenetic Memory     435
Chapter 17  Epigenetics of Health and Disease--Cancer     465
Chapter 18  Epigenetics of Health and Disease--Behavioral Neuroscience     499
Chapter 19  Epigenetics of Health and Disease--Diet and Toxicology, Environmental Exposures     523
Chapter 20  Epigenetics and Technology--Hairpin-Based Antisensing     555
Index     577