Immunity and Inflammation in Health and Disease

Shampa Chatterjee is Associate Professor at the Department of Physiology, University of Pennsylvania School of Medicinein Philadelphia. Trained in India, Germany and the US, her current research is on inflammation-immune signaling with a focus on the vascular system. Her lab studies the role of redox signals in the onset and amplification of inflammation and immune responses. Toward this, recent work from her group showed that the systemic cytokine storm associated with COVID-19 activates an inflammation cascade in the vascular system that can potentially lead to vascular dysfunction. Research in her lab is funded by extramural research funding from the NIH and corporate sources. Dr. Chatterjee serves on the Editorial Board of several journals in the field of pulmonary physiology. She has published more than 100 papers in peer reviewed journals and edited two books on Endothelial Signaling, and on Inflammation and Immune responses. Dr. Chatterjee has received numerous awards such as the Caroline Tum Suden young Investigator Award, and the Hermann Rahn award for Excellence if Pulmonary Physiology. The topics addressed in this book are central to her research where she tries unraveling the balance between the onset of inflammation in host protection and resolution of inflammation in host injury. Wolfgang Jungraithmayr MD, PhD is a transplant surgeon and immunologist with a research interest in the field of transplant and tumor immunology. His lab has unraveled some of the signaling events that follow the transplant procedure and that lead to allograft rejection post lung transplant. He is professor of thoracic surgery at the University of Zurich, Switzerland, and the Medical University Brandenburg, Germany. Wolfgang Jungraithmayr published more than 70 original articles and received several awards, among them the Grillo Award of the European Society of Thoracic Surgeons Debasis Bagchi, PhD, MACN, CNS, MAIChE, received his Ph.D. in Medicinal Chemistry in 1982. He is a Professor in the Department of Pharmacological and Pharmaceutical Sciences at the University of Houston College of Pharmacy, Houston, TX, and Chief Scientific Officer at Cepham Research Center, Piscataway, NJ, Adjunct Faculty in Texas Southern University, Houston, TX. He served as the Senior Vice President of Research & Development of InterHealth Nutraceuticals Inc, Benicia, CA, from 1998 until Feb 2011, and then as Director of Innovation and Clinical Affairs, of Iovate Health Sciences, Oakville, ON, until June 2013. Dr. Bagchi received the Master of American College of Nutrition Award in October 2010. He is the Past Chairman of International Society of Nutraceuticals and Functional Foods (ISNFF), Past President of American College of Nutrition, Clearwater, FL, and Past Chair of the Nutraceuticals and Functional Foods Division of Institute of Food Technologists (IFT), Chicago, IL. He is serving as a Distinguished Advisor on the Japanese Institute for Health Food Standards (JIHFS), Tokyo, Japan. Dr. Bagchi is a Member of the Study Section and Peer Review Committee of the National Institutes of Health (NIH), Bethesda, MD. He has published 321 papers in peer reviewed journals, 30 books, and 18 patents. Dr. Bagchi is also a Member of the Society of Toxicology, Member of the New York Academy of Sciences, Fellow of the Nutrition Research Academy, and Member of the TCE stakeholder Committee of the Wright Patterson Air Force Base, OH. He is also Associate Editor for the Journal of Functional Foods, Journal of the American College of Nutrition, and the Archives of Medical and Biomedical Research, and is also serving as Editorial Board Member of numerous peer reviewed journals, including Antioxidants & Redox Signaling, Cancer Letters, Toxicology Mechanisms and Methods, and The Original Internist, among others.

Section I: Innate and Adaptive Immune Systems: Components and Regulation 1. Innate and Adaptive Immunity: Barriers and Receptor Based Recognition 2. Innate Immunity at Birth: Implications for Inflammation and Infection in Newborns 3. Redox Signaling and Onset of the Inflammatory Cascade

Section II: Reactive Oxygen Species, Oxidative Stress and Immune Cell Activation 4. Reactive Oxygen Species, Oxidative Damage and Cell Death 5. Mitochondrial ROS and T Cell Activation 6. Oxidants and Inflammation: Endothelial Targeting Of Antioxidants to Combat Disease 7. Oxidative Signaling In Chronic Obstructive Airway Diseases

Section III: Inflammatory Systems: Mechanistic Pathways Of Stimulation and Suppression 8. Immune Responses in the Upper Respiratory Tract in Health and Disease 9. The Biological Role of NADPH Oxidases in Pulmonary Ischemia-Reperfusion Injury in Pulmonary Inflammation 10. Receptor Blockade of CD26/DPP4 as a Therapeutic Strategy Against I/R Injury and Lymphocytic Inflammation And Its Clinical Implications 11. DPPIV/CD26 as A Target in Anti-Inflammatory Therapy 12. Redox Sensitive Transcription via Nrf2-Keap1 in Suppression of Inflammation

Section IV: Immunity and Inflammation: Common Threads Of Multifactorial Diseases 13. Monogenic Defects of Toll-Loke receptor Signaling and Primary Immunodeficiency 14. PPAthogen - and Microbial- Associated Molecular Patterns (PAMPs/MAMPs) in the Innate Immune Response in Crohn's Disease 15. Inflammation and Calcification in the Vascular Tree; Insights into Atherosclerosis 16. From Inflammation to Cancer: Opportunites for Chemoprevention via Dietary Intervention 17. Inflammation in Bullous Pemphigoid, a Skin Auto-Immune Disease 18. Inflammation in Systemic Immune Diseases: Role of TLR9 Signaling and the Resultant Oxidative Stress in Pathology of Lupus

Section V: Nutraceuticals in Boosting Immune Support and as Therapeutics for Inflammatory Diseases 19. Anti-inflammatory and Anti-microbial Properties of Achillea millefolium in Acne Treatment 20. Lactobacillus Gasseri Potentiates Immune Response Against Influenza Virus Infection 21. Micronutrients in Skin Immunity and Associated Diseases 22. Mycobiome and Gut Inflammation: Implications in Inflammatory Bowel Disease 23. Flavonoids in Treating Psoriasis 24. Probiotics and Anti-Inflammatory Processes in HIV Infected: From Benchside Research to Bedside 25. Chronic Inflammation in Asthma: Anti-Malarial Drug Artesunate as a Therapeutic Agent 26. Nutrition as a Tool to Reverse Immunosenescence?

Section VI: New Perspectives and Future Directions 27. Therapeutic Interventions to Block Oxidative Stress-Associated Pathologies 28. Phytochemicals as Anti-Inflammatory Nutraceuticals and Phytophamaceuticals 29. Fermented Milk in Protection Against Inflammatory Mechanisms In Obesity 30. Prebiotics and Probiotics in Altering Microbiota: Implications in Colorectal Cancer 31. Naturopathy and Lifestyle Interventions in Boosting Immune Responses in HIV Positive Population 32. Eating Habits and Fighting Disease: Nutraceuticals and Functional Foods at the Intersection of Immune Health and Inflammatory Responses