Cardiac Electrophysiology: From Cell to Bedside

Distinguished Senior Investigator, Centro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.), Madrid, Spain. Emeritus Professor of Internal Medicine and Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan. Dr Jalife is also actively conducting research at the Centro Nacional de Investigaciones Cardiovasculares, in Madrid, Spain. William Gregory Stevenson, MD, is Professor of Medicine at Vanderbilt University School of Medicine in Nashville, Tennessee. Dr Jalife will assume the role of lead editor on the 8th edition with Douglas Zipes's retirement

Section 1 Structural and Molecular Bases of Ion Channel Function

1. Voltage-Gated Sodium Channels and Electrical Excitability of the Heart

2. Voltage-Gated Calcium

3. Voltage-Gated Potassium Channels

4. Structural and Molecular Bases of Cardiac Inward Rectifier Potassium Channel Function

5. Mammalian Calcium Pumps in Health and Disease

6. Structural and Molecular Bases of Sarcoplasmic Reticulum Ion Channel Function

7. Organellar Ion Channels and Transporters

8. Molecular Organization, Gating and Function of Connexin-based Gap Junction Channels and Hemichannels

Section 2 Biophysics of Cardiac Ion Channel Function

9. Structure-function relations of Heterotrimetric complexes of sodium channel a and ß subunits

10. Regulation of Cardiac Calcium Channels

11. Inhibition of Phosphoinositide 3-Kinase and Acquired Long QT Syndrome

12. Structural Determinants and Biophysical Properties of hERG1 Channel Gating

13. Molecular Regulation of Cardiac Inward Rectifier Potassium Channels by Pharmacological Agents

14. Cardiac Stretch-Activated Channels and Mechano-Electric Coupling

15. Biophysical Properties of Gap Junctions

16. Excitation-Contraction Coupling

Section 3 Intermolecular Interactions and Cardiomyocyte Electrical Function

17. Ion Channel Trafficking in the Heart

18. Microdomain Interactions of Macromolecular Complexes and Regulation of the Sodium Channel Nav1.5

19. Fibroblast growth factor homologous factors modulate cardiac calcium channels.

20. Macromolecular Complexes and Cardiac Potassium Channels

21. Reciprocity of Cardiac Sodium and Potassium Channels in the Control of Excitability and Arrhythmias

22. The intercalated disc: A molecular network that integrates electrical coupling, intercellular adhesion and cell excitability

23. Function and dysfunction of ion channel membrane trafficking and post translational modification

24. Feedback Mechanisms for Cardiac-Specific microRNAs and cAMP Signaling in Electrical Remodeling.

Section 4 Cell Biology of Cardiac Impulse Initiation and Propagation

25. Stem cell-derived nodal-like cardiomyocytes as a novel pharmacologic tool: insights from sinoatrial node development and function.

26. Gene Therapy and Biological Pacing

27. Intercellular Communication and Impulse Propagation

28. Mechanisms of normal and dysfunctional Sinoatrial Nodal Excitability and Propagation

29. Cell Biology of the Specialized Cardiac Conduction System

30. Cardiac Remodeling and Regeneration

Section 5 Models of Cardiac Excitation

31. Ionic Mechanisms of Atrial Action Potentials

32. Genetic algorithms to generate dynamical complexity electrophysiological models

33. Calcium Signaling in Cardiomyocyte Models with Realistic Geometries

34. Theory of Rotors and Arrhythmias

35. Computational approaches for Accurate Rotor localization in the Human Atria

36. Modeling the aging heart

Section 6 Neural Control of Cardiac Electrical Activity

37. Innervation of the sinoatrial node

38. Mechanism for altered autonomic and oxidant regulation of cardiac sodium currents.

39. Pulmonary Vein Ganglia and the Neural Regulation of the Heart Rate

40. Neural Activity and Atrial Tachyarrhythmias

41. Sympathetic Innervation and Cardiac Arrhythmias

Section 7 Arrhythmia Mechanisms

42. The Molecular Pathophysiology of Atrial Fibrillation

43. Myofibroblasts, Cytokines, and Persistent Atrial Fibrillation

44. Role of the Autonomic Nervous System in Atrial Fibrillation

45. Rotors in Human Atrial Fibrillation

46. Body surface frequency-phase mapping of atrial fibrillation.

47. Panoramic Mapping of Atrial Fibrillation from the body surface

48. Mechanisms of Human Ventricular Tachycardia and Human Ventricular Fibrillation

49. Genetics of Atrial Fibrillation

Section 8 Molecular Genetics and Pharmacogenomics

50. Mechanisms in Heritable Sodium Channel Diseases

51. Genetic, Ionic and Cellular Mechanisms Underlying the J Wave Syndromes

52. Inheritable Potassium Channel Diseases

53. Inheritable Phenotypes Associated With Altered Intracellular Calcium Regulation

Section 9 Pharmacologic, Genetic and Cell Therapy of Ion Channel Dysfunction

54. Pharmacologic Bases of Antiarrhythmic Therapy

55. Pharmacogenomics of Cardiac Arrhythmias

56. Gene therapy to treat cardiac arrhythmias

57. Highly Mature Human iPSC-Derived Cardiomyocytes as Models for Cardiac Electrophysiology and Drug Testing

58. Cardiac repair with human induced pluripotent stem cell-derived cardiovascular cells.

Section 10 DIAGNOSTIC EVALUATION

59. Assessment of the patient with a cardiac arrhythmia

60. Electrocardiography of tachyarrhythmias: Differential diagnosis of narrow and wide QRS complex tachycardias

61. Electroanatomic Mapping for arrhythmias

62. Computed tomography for electrophysiology

63. Magnetic resonance imaging for electrophysiology

64. Intracardiac echocardiography for electrophysiology

65. Exercise-induced arrhythmias

66. Cardiac monitoring: short- and long-term recording

67. Head-up Tilt Table Testing

68. Autonomic Regulation and Cardiac Risk

69. T-wave alternans

70. Noninvasive Electrocardiographic Imaging of Human Ventricular Arrhythmias and Electrophysiological Substrate

71. Genetic testing

Section 11 SUPRAVENTRICULAR TACHYARRHYTHIAS: MECHANISMS, CLINICAL FEATURES, AND MANAGEMENT

72. Sinus node abnormalities

73. Atrial tachycardia

74. Atrial tachycardia in adults with congenital heart disease

75. Typical and Atypical Atrial Flutter: Mapping and Ablation

76. Atrial fibrillation

77. Preexcitation, Atrioventricular reentry, Variants

78. Electrophysiological Characteristics of Atrioventricular Nodal Reentrant Tachycardia: Implications for the Rentrant Circuits

79. Junctional tachycardia

Section 12 VENTRICULAR TACHYCARRHYTHMIAS: MECHANISMS, CLNICAL FEATURES, AND MANAGEMENT

80. Premature ventricular complexes

81. Outflow tract ventricular tachycardias: Mechanisms, Clinical Features, and Management

82. Fascicular ventricular arrhythmias

83. Bundle branch reentry tachycardia

84. Ischemic heart disease

85. Ventricular Tachycardia in Patients with Dilated Cardiomyopathy

86. Ventricular Arrhythmias in Hypertrophic Cardiomyopathy

87. Ventricular Tachycardias in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

88. VTs in Catcholaminergic Cardiomyopathy (Catecholaminergic polymorphic ventricular tachycardia)

89. Ventricular Arrhythmias in Heart failure

90. Arrhythmias and conduction disturbances in Non Compaction Cardiomyopathy

91. Takotsubo cardiomyopathy

92. Brugada syndrome

93. Long and short QT syndromes

94. Anderson-Tawil syndrome

95. Timothy syndrome

96. J Wave Syndromes

97. Idiopathic ventricular fibrillation

98. Sudden infant death syndrome

99. Sudden cardiac arrest/death in adults

100. Neurologic disorders

101. Drug-Induced Ventricular Tachycardia

102. Ventricular Arrhythmias in Congenital Heart Disease

Section 13 SYNCOPE and Bradyarrhythmias

103. Syncope

104. Postural orthostatic tachycardia syndrome

105. Progressive conduction system disease

106. Atrioventricular block

Section 14 ARRHYTHMIAS IN SPECIAL POPULATIONS PHARMACOLOGIC THERAPY

107. Sex differences in arrhythmias

108. Sudden cardiac death in athletes, inlcuding commotio cordis

109. Pediatric populations

110. Sleep-disordered breathing and arrhythmias

111. Ventricular Assist devices and Cardiac Transplantation Recipients

Section 15 PHARMACOLOGIC THERAPY

112. Standard antiarrhythmic drugs

113. Innovations In Antiarrhythmic Drug Therapy

114. Nontraditional drugs for sudden cardiac death

115. Prevention of stroke in atrial fibrillation: warfarin, anti-factor Xa and thrombin drugs

Section 16 CARDIAC IMPLANTABLE ELECTRONIC DEVICES

116. Implantable cardioverter defibrillators: technical aspects

117. Implantable cardioverter defibrillators: clinical aspects

118. Subcutaneous implantable defibrillator

119. Implantable pacemakers

120. Cardiac resynchronization therapy

121. Newer applications of pacemakers

122. Remote monitoring

Section 17 CATHETER ABLATION

123. Catheter Ablation: Technical aspects

124. Catheter Ablation: Clinical aspects

125. Ablation for Atrial fibrillation

126. Ablation of Supraventricular tachycardias

127. Catheter Abliation for Ventricular tachycardias with/without structural heart disease

128. Epicardial and other approaches

129. Ventricular fibrillation

130. Ablation in Pediatrics

131. Congenital heart disease

132. Anesthesiology for EP procedures

Section 18: SURGERY FOR ARRHYTHMIAS

133. Surgery for Atrial fibrillation and other supraventricular tachycardias

134. Surgery for Ventricular tachycardia

Section 19 NEW APPROACHES

135. Cervical vagal stimulation for heart failure

136. Baroreflex stimulation

137. Spinal cord stimulation for heart failure and Arrhythmias

138. Renal artery denervation

139. Left atrial appendage occlusion/ligation