The Development of Iron Chelators for Clinical Use

Bergeron, Raymond J.; Brittenham, Gary M.

Physiology and Pathophysiology of Iron Metabolism: Implications for Iron Chelation Therapy in Iron Overload (P. Ponka). Iron, Oxidative Damage and Chelating Agents (B. Halliwell). Iron Chelation Therapy in the Treatment of Iron Overload (M.J. Pippard). Potential Clinical Applications of Iron Chelating Therapy (C. Hershko, G. Link, M. Tzahor, and A. Pinson). Iron Withholding: The Natural Defense System and Its Modification by Pharmacologic Agents (E.D. Weinberg). Iron Chelation as a Chemotherapeutic Strategy in the Treatment of Malaria (V.R. Gordeuk, G.M. Brittenham, and P.E. Thuma). Towards Better Chelation Therapy: Current Concepts and Research Strategy (H.P. Schnebli, I. Hassan, K.O. Hamilton, S. Lynch, Y. Jin, H.P. Nick, H.H. Peter, U. Junker Walker, R. Ziel, S.C. Khanna, R. Dean, and R.J. Bergeron). Siderophores as Biological Deferration Agents and the Regulation of their Synthesis by Iron (J.B. Neilands). Biochemical and Genetic Studies on Lysine: N6-hydroxylase Involved in Aerobactin Synthesis (A.M. Thariath, M.A. Valvano, and T. Viswanatha). The Ferrichrome Biosynthetic Pathway of Ustilago maydis Reveals Similarities to the Aerobactin Pathway of Escherichia Coli and to Globin Gene Regulation in Erythroid Cells (S.A. Leong, B. Mei, C. Voisard, A. Budde, J. McEvoy, J. Wang, P. Xu, and B. Saville). Ability of Catecholate Derivatives to Promote Growth of Gram-Negative Bacteria (R. Reissbrodt and W. Rabsch). Synthesis and Biological Activity of Hydroxamate-Based Iron Chelators (R.J. Bergeron and J.S. McManis). Siderophore-Mediated Drug Delivery: The Design, Synthesis, and Study of Siderophore-Antibiotic and Antifungal Conjugates (M.J. Miller and F. Malouin). Siderophore-Based Hydroxypyridonate Sequestering Agents (K.N. Raymond and J. Xu). Ligand Design of Chelating Agents Effective in the Coordination of Fe(III) and for the Removal of Iron in Cases of Iron Overload (A.E. Martell, R.J. Motekaitis, Y. Sun, and E.T. Clarke). The Design of Therapeutically Useful Iron