Immunotherapy of Melanoma (eBook)
XI, 434 Seiten
Springer International Publishing (Verlag)
978-3-319-48066-4 (ISBN)
Metastatic melanoma are introduced to the readers, giving details of the diagnosis, clinical symptoms, types and AJCC staging, followed by a discussion of problems in the treatment of melanoma and how immunotherapy provided the solution. Next an account of the immune system is given, describing its role in cancer prevention and discussing how immune check points are circumvented in cancer. Approved drugs are discussed together with their molecular mechanisms of action, response rates, survival benefits, pharmacokinetics and adverse effects. Finally this book discusses the most promising candidates from ongoing clinical trials and highlights challenges faced by immunotherapeutic drugs as well as strategies to overcome them.
Metastatic melanoma is a deadly type of skin cancer, known for its resistance to conventional treatments. For decades, patients were managed with a handful of drugs that had minimal survival benefits. The scenario changed with the approval of inhibitors of BrafV600E and MEK, and monoclonal antibodies against CTLA4. While the kinase inhibitors were promising in the initial studies, they suffered with the development of lethal resistance. Anti-CTLA4 monoclonal antibodies (Ipilimumab) on the other hand provided long term survival benefits in responding patients and there were no reports of resistance. However, response rate for Ipilimumab was very low. Recently, monoclonal antibodies against PD-1 receptors (Nivolumab, Pembrolizumab) were approved by FDA for the treatment of melanoma, extending the hope for melanoma patients. This book provides detailed information on immunotherapeutic drugs for melanoma management - it describes melanoma, discusses issues in melanoma treatment and highlights the successes of immunotherapy in the treatment.
ContentsPreface
1. Melanoma
1.1 Introduction, history and epidemiology
1.2 Diagnosis, subtypes and staging
1.3 Etiology
1.4 Treatment
2. Tumor immunology
2.1 Overview of immune system
2.2 Dendritic cells
2.3 T-cells
2.4 Mechanisms of immune evasion by cancer
3. Immune based drugs approved for treatment of melanoma 3.1 IFN-α2b
3.2 IL-2
3.3 Ipilimumab
3.4 Nivolumab
3.5 Pembrolizumab
3.6 Talimogene laherparepvec
4. Promising immunotherapeutic approaches in clinical trials
4.1 Introduction
4.2 Monoclonal antibodies
4.3 Cytokines
4.4 Cancer vaccines
p; 4.5 Dendritic cells
4.6 Adoptive cell therapy
5. Challenges of immunotherapyIndex
Erscheint lt. Verlag | 19.12.2016 |
---|---|
Zusatzinfo | XI, 434 p. 59 illus., 52 illus. in color. |
Verlagsort | Cham |
Sprache | englisch |
Themenwelt | Medizin / Pharmazie ► Studium |
Schlagworte | Adoptive cell therapy • cancer vaccines • Check point blockers • immunotherapy • melanoma |
ISBN-10 | 3-319-48066-9 / 3319480669 |
ISBN-13 | 978-3-319-48066-4 / 9783319480664 |
Haben Sie eine Frage zum Produkt? |
![PDF](/img/icon_pdf_big.jpg)
Größe: 8,0 MB
DRM: Digitales Wasserzeichen
Dieses eBook enthält ein digitales Wasserzeichen und ist damit für Sie personalisiert. Bei einer missbräuchlichen Weitergabe des eBooks an Dritte ist eine Rückverfolgung an die Quelle möglich.
Dateiformat: PDF (Portable Document Format)
Mit einem festen Seitenlayout eignet sich die PDF besonders für Fachbücher mit Spalten, Tabellen und Abbildungen. Eine PDF kann auf fast allen Geräten angezeigt werden, ist aber für kleine Displays (Smartphone, eReader) nur eingeschränkt geeignet.
Systemvoraussetzungen:
PC/Mac: Mit einem PC oder Mac können Sie dieses eBook lesen. Sie benötigen dafür einen PDF-Viewer - z.B. den Adobe Reader oder Adobe Digital Editions.
eReader: Dieses eBook kann mit (fast) allen eBook-Readern gelesen werden. Mit dem amazon-Kindle ist es aber nicht kompatibel.
Smartphone/Tablet: Egal ob Apple oder Android, dieses eBook können Sie lesen. Sie benötigen dafür einen PDF-Viewer - z.B. die kostenlose Adobe Digital Editions-App.
Buying eBooks from abroad
For tax law reasons we can sell eBooks just within Germany and Switzerland. Regrettably we cannot fulfill eBook-orders from other countries.
aus dem Bereich