Increasing the Therapeutic Ratio of Radiotherapy (eBook)

Philip J. Tofilon, Ph.D., is Senior Investigator, Radiation Oncology Branch, National Cancer Institute. Kevin Camphausen, MD, is Branch Chief, Senior Investigator, Radiation Oncology Branch, National Cancer Institute.

Part 1. Molecular Targets.- 1. Improving the therapeutic ratio of radiotherapy by targeting the DNA Damage Response.- 2. Receptor Tyrosine Kinases as Targets for Enhancing Tumor Radiosensitivity.- 3. Histone Deacetylase Inhibitors and Tumor Radiosensitization.- 4. Radioprotection as a Method to Enhance the Therapeutic Ratio of Radiotherapy.- Part 2. Microenvironment.- 5. Application of Functional Molecular Imaging in Radiation Oncology.- 6. Remodeling the Irradiated Tumor Microenvironment: The 5th R of Radiobiology?.- 7. Combining Radiotherapy and Immunotherapy: Emerging Preclinical Observations of Lymphocyte Costimulatory and Inhibitory Receptor Modulation.- Part 3. Clinical.- 8. Stereotactic Body Radiation Therapy (SBRT) or Alternative Fractionation Schedules.- 9. Novel Imaging for Treatment Planning or Tumor Response.- 10. Increasing the Therapeutic Efficacy of Radiotherapy Using Nanoparticles.- Index.