Recent Progress on Gnrh and Gonadal Peptides

Preface. List of Contributors. Session I - GnRH. Gonadotropin-releasing hormone (GnRHe generalities (G. Schaison). Gonadotropin-releasing hormone: gene structure, expression and secretion (K. Nikolies, P.H. Seeburg). Molecular mechanism of action of gonadotropin-releasing hormone (GnRHe (K. Natarajan, P.M. Conn). Gonadotropin-releasing hormone (GnRHe secretion during the preovulatory luteinizing hormone (LHe surge in the ewe (A. Caraty, S.M. Moenter, A. Locatelli, G.B. Martin, F.J. Karsch). Current concepts of the hypothalamic control of follicle-stimulating hormone secretion (M.D. Culler, A. Negro-Vilar). GnRH receptors: pharmacology and visualization in brain, ovary and placenta (F. Haour, M. Crumeyrolle-Arias, J. Latouche, P. Leblanc, N. Olivier, B. Augendre-Ferrante, J.F. Heurtier, E. Ban). Extrapituitary actions of GnRH and analogs (T.M. Siler-Khodr, I.S. Kang, T.J. Kuehl, G.S. Khodr, M.J.K. Harper). Technology of luteinizing hormone (LHe pulse analysis (H. Lejeune, P. Billion, A. Charrie, M.C. Fleury, M. El Midani, J. Tourniaire, M. Pugeat). Qualitative aspects of GnRH analogue action of gonadotropin secretion (M. Roger, N. Lahlou, B. Couzinet, J.L. Chaussain, P. Bouchard, G. Schaison). Session II - GnRH analogs. The development of safer GnRH antagonists: strategy and status (M.J. Karten, C.A. Hoeger, W.A. Hook, M.C. Lindberg, R.H. Naqvi). Drug delivery of peptides (B. Tissier). Primate studies with antide (Nal-Lys GnRH antagoniste (G.D. Hodgen). Contraceptive studies with GnRH analogs in men and non-human primates (G.F. Weinbauer, H.M. Behre, E. Nieschlag). LHRH antagonists: clinical studies in man (S.N. Pavlou, C.R. DeBold, D.N. Orth). Mechanisms of action and clinical uses of GnRH antagonists in women (P. Bouchard, A. Caraty, D. Medalie, M.R. Massai, S. Dubourdieu, B. Charbonnel, R. Frydman, Y.Y. Tsong, G. Schaison, I.M. Spitz). Clinical aspects of GnRH antagonists: round table (M.J. Karten, P. Bouchard, R. Frydman, G.D. Hodgen, S.L. Lightman, E. Nieschlag, S.N. Pavlou, J. Salat-Baroux, T. Siler-Khodr, I. Spitz, G. Tolis). Three years of experience in the treatment of precocious puberty with a slow-release preparation of D-Trp 6 -LHRH (C. Couprie, J.E. Toublanc, M. Roger, J.L. Chaussain). Treatment of endometriosis with a delayed-release preparation of the agonist D-Trp 6 -LHRH: long-term follow-up in a series of 50 patients (J.R. Zorn, J. Mathieson, F. Risquez, A.M. Comaru-Schally, A.V. Schally). Clinical aspects of GnRH agonists: use in endometriosis-related infertility (B. Hedon, V. Virenque, B. Bachelard, P. Boulot, F. Audibert, P. Benos, F. Arnal, C. Humeau, J. Bringer, N. Fries, P. Mares, F. Laffargue, J.L. Viala). Treatment of uterine leiomyomas with an LHRH agonist: results of a study of 42 patients with a mean follow-up of 16 months (J. Cohen, D. Elia). Use of GnRH analogs in in vitro fertilization (IVFe (R. Frydman). Clinical aspects of GnRH in polycystic ovarian disease (J. Salat-Baroux, S. Alvarez, P. Franchimont).