Biochemical Basis of Functional Neuroteratology

Section 1 - Outlines of Functional Neuroteratology. 1. Concept of functional neuroteratology and the importance of neurochemistry (D.F. Swaab, G.J. Boer and M.G.P. Feenstra). 2. Defects of neuronal migration and the pathogenesis of cortical malformation (P. Rakic). 3. Implications of behavioral teratology for assessing the risks posed by environmental and therapeutic chemicals (B. Weiss). 4. Problems in studying functional teratogenicity in man (H.J. Huisjes). 5. Behavioural teratology of exogenous substances: regulation aspects (H.B.W.M. Koeter). Section 2 - Lasting Effects of Early Hormone Imbalance . 6. Teratogenic mechanisms of dysthyroidism in the central nervous system (A. Vaccari). 7. The role of the insulin-like growth factors in the regulation of brain development (V.R. Sara and C. Carlsson-Skwirut). 8. Stress, glucocorticoids and development (E.R. De Kloet, P. Rosenfeld, J.A.M. Van Eeekelen, W. Sutanto and S. Levine). 9. Actions of sex hormones on the brain: "organization" and "activation" in relation to functional teratology (B.S. McEwen). Section 3 - Neuroactive Drugs as Functional Teratogen . 10. Prenatal adverse effects of nicotine on the developing brain (W. Lichtensteiger, U. Ribary, M. Schlumpf, B. Odermatt and H.R. Widmer). 11. Functional deprivation of noradrenaline neurotransmission: effects of clonidine on brain development (M. Mirmiran, M.G.P. Feenstra, F.A. Dijcks, N.P.A. Bos and F. Van Haaren). 12. Long-lasting changes after perinatal exposure to antidepressants (J. Del Rio, D. Montero and M.L. De Ceballos). 13. Placental and blood element neurotransmitter receptor regulation in humans: potential models for studying neurochemical mechanisms underlying behavioral teratology (B.D. Perry). 14. Benzodiazepines: influence on the developing brain (C.K. Kellogg). 15. Anticonvulsants and brain development (C.V. Vorhees, D.R. Minck and H.K. Berry). 16. Neuropeptides and functional neuroteratology (G.J. Boer, F.G.M. Snijdewint and D.F. Swaab). 17. Perinatal exposure to methadone: how do early biochemical alterations cause neurofunctional disturbances? (T.A. Slotkin). Section 4 - Food and Environmental Factors . 18. Excitotoxic food additives: functional teratological aspects (J.W. Olney). 19. Organometals and brain development (Z. Annau). Alcohol as a social teratogen (B.E. Leonard). 21. Prenatal stress effects on functional development of the offspring (M. Weinstock, E. Fride and R. Hertzberg). Section 5 - Neurochemical Mechanisms . 22. Structural-functional relationships in experimentally-induced brain damage (P.M. Rodier). 23. Coordination of cell development by the ornithine decarbozylase (ODC) polyamine pathway as an underlying mechanism in developmental neurotoxic events (J.M. Bell and T.A. Slotkin). 24. Neurotransmitters as morphogens (J.M. Lauder). 25. Brain cell acquisition and neurotropic drugs with special reference to functional teratogenesis (A.J. Patel and P.D. Lewis). 26.