Disorders of Sleep and Circadian Rhythms in Parkinson's Disease

Dr. Aleksandar Videnovic is Assistant Professor of Neurology at Northwestern University Feinberg School of Medicine in Chicago, USA. His clinical and research expertise is in Parkinson's Disease and movement disorders and in Sleep Medicine. Dr. Videnovic's research has been focused on sleep dysfunctions in movement disorders with an emphasis on Parkinson's disease. His research is supported by the United States National Institute of Health, the American Academy of Neurology Foundation, the Michael J. Fox Foundation for Parkinson Research, and the National Parkinson Foundation. Dr. Birgit Högl is Professor of Neurology at Innsbruck Medical University in Innsbruck, Austria. She is a world-renowned expert in the field of Sleep Medicine. Professor Högl has authored many landmark studies related to the interface of sleep and movement disorders, in particular Parkinson's disease, REM Sleep Behavior Disorder and Restless Legs Syndrome.

Part I.- 1. Introduction: Sleepy days and restless nights of Parkinson's Disease.- 2. Regulation of sleep and wake homeostasis.- 3. Neurochemistry of the sleep-wake cycle in Parkinson's disease.- 4. Impaired sleep and alertness in Parkinson's disease: what did we learn from animal models?.- 5. Objective measures of the sleep-wake cycle in Parkinson's disease.- 6. Subjective assessment of sleep and sleepiness in Parkinson's disease.Part II.- 7. Excessive daytime somnolence associated with Parkinson's disease.- 8. Insomnia in Parkinson's disease.- 9. Sleep-disordered breathing in Parkinson's disease.- 10. Restless legs syndrome and periodic limb movement disorder in Parkinson's disease.- 11. REM sleep behavior disorder.- 12. REM sleep behavior disorder: a pre-motor marker of Parkinson's disease.- 13. Dysregulation of circadian system in Parkinson's disease.- 14. Cognition and the sleep-wake cycle in Parkinson's disease.- 15. Fatigue and sleepiness in Parkinson's disease.- 16. Impact of surgical therapies on sleep and alertness in Parkinson's disease.- 17. Future directions.

"This book, written and edited by internationally recognized clinician-scientists in the field, is a welcome addition to the sleep medicine, movement disorder, and neuropsychiatric literature. The authors wish to discuss how 'specific sleep disorders have emerged as important early manifestations of synuclein related neurodegeneration specific for PD'. ... This is an excellent, unique, and useful book targeted at clinicians involved in the care of patients with PD and related disorders." (Michael Joel Schrift, Doody's Book Reviews, October, 2015)