Myeloid Cells in Health and Disease

Contributors


Preface


Acknowledgments


About the Editor


SECTION I INTRODUCTION AND HISTORY


1 Paul Ehrlich and the Early History of Granulocytes


A. Barry Kay


2 The Phagocyte, Metchnikoff, and the Foundation of Immunology


Giuseppe Teti, Carmelo Biondo, and Concetta Beninati


3 Growth and Differentiation Factors


Donald Metcalf and Nicos A. Nicola


SECTION II GENERAL ASPECTS


4 Evolution of Myeloid Cells


Daniel R. Barreda, Harold R. Neely, and Martin F. Flajnik


5 Advances on Myeloid Like-Cell Origins and Functions in the Model Organism Drosophila melanogaster


Laure El Chamy, Nicolas Matt, and Jean-Marc Reichhart


6 Monocyte, Macrophage, and Dendritic Cell Development: the Human Perspective


Matthew Collin and Venetia Bigley


7 Myeloid Cell Turnover and Clearance


William J. Janssen, Donna L. Bratton, Claudia V. Jakubzick, and Peter M. Henson


SECTION III SPECIALIZATION


8 Transcriptional Regulation and Macrophage Differentiation


David A. Hume, Kim M. Summers, and Michael Rehli


9 Murine Monocytes: Origins, Subsets, Fates, and Functions


Alexander Mildner, Goran Marinkovic, and Steffen Jung


10 Dendritic Cells in the Immune System—History, Lineages, Tissues, Tolerance, and Immunity


Jonathan M. Austyn


11 Antigen Processing and Presentation Mechanisms in Myeloid Cells


Paul A. Roche and Peter Cresswell


12 Microglia


V. Hugh Perry


13 Osteoclasts—Key Players in Skeletal Health and Disease


Deborah Veis Novack and Gabriel Mbalaviele


14 The Regulatory Function of Eosinophils


Ting Wen and Marc E. Rothenberg


SECTION IV RECRUITMENT, INFLAMMATION, AND REPAIR


15 Intravital Imaging of Myeloid Cells: Inflammatory Migration and Resident Patrolling


Justin F. Deniset and Paul Kubes


16 Multifaceted Functions of NOD-Like Receptor Proteins in Myeloid Cells at the Intersection of Innate and Adaptive Immunity


Thomas A. Kufer, Giulia Nigro, and Philippe J. Sansonetti


17 Inflammasomes in Myeloid Cells: Warriors Within


Sushmita Jha and Jenny Pan-Yun Ting


18 Inflammation—a Critical Appreciation of the Role of Myeloid Cells


Asif J. Iqbal, Edward A. Fisher, and David R. Greaves


19 Lipid Mediators in Inflammation


Melanie Bennett and Derek W. Gilroy


20 Macrophage Proresolving Mediators—the When and Where


Jesmond Dalli and Charles Serhan


21 Myeloid Cells in Cutaneous Wound Repair


Jenna L. Cash and Paul Martin


SECTION V RECOGNITION, SIGNALING, AND GENE EXPRESSION


22 The Role and Function of Fcγ Receptors on Myeloid Cells


Stylianos Bournazos, Taia T. Wang, and Jeffrey V. Ravetch


23 Complement Receptors in Myeloid Cell Adhesion and Phagocytosis


Michael L. Dustin


24 Toll-Like Receptor Signaling and Its Inducible Proteins


Takashi Satoh and Shizuo Akira


25 Lectin Receptors Expressed on Myeloid Cells


Gordon D. Brown and Paul R. Crocker


26 G Protein-Coupled Receptors in Macrophages


Hsi-Hsien Lin and Martin Stacey


27 Molecular Mechanisms of Phagosome Formation


Valentin Jaumouillé and Sergio Grinstein


28 Role of the Cytoskeleton in Myeloid Cell Function


Noah Fine, Samira Khaliq, Siavash Hassanpour, and Michael Glogauer


29 Coordinated Regulation of Signaling Pathways during Macrophage Activation


Toby Lawrence


30 Genome-Wide Approaches to Defining Macrophage Identity and Function


Gregory J. Fonseca, Jason S. Seidman, and Christopher K. Glass


31 Epigenetic Regulation of Myeloid Cells


Lionel B. Ivashkiv and Sung Ho Park


SECTION VI SECRETION AND DEFENSE


32 Secretion from Myeloid Cells: Secretory Lysosomes


Gillian M. Griffiths


33 The NADPH Oxidase and Microbial Killing by Neutrophils, With a Particular Emphasis on the Proposed Antimicrobial Role of Myeloperoxidase within the Phagocytic Vacuole


Adam P. Levine and Anthony W. Segal


34 Evolution of Cell-Autonomous Effector Mechanisms in Macrophages versus Non-Immune Cells


Ryan G. Gaudet, Clinton J. Bradfield, and John D. MacMicking


35 Anti-TNF Therapy


Irina Udalova, Claudia Monaco, Jagdeep Nanchahal, and Marc Feldmann


36 Metalloproteinases: a Functional Pathway for Myeloid Cells


Jonathan Chou, Matilda F. Chan, and Zena Werb


SECTION VII IMMUNOREGULATION AND INFECTION


37 Interplay between Myeloid Cells and Humoral Innate Immunity


Sébastien Jaillon, Eduardo Bonavita, Cecilia Garlanda, and Alberto Mantovani


38 Adaptive Characteristics of Innate Immune Responses in Macrophages


Rob J. W. Arts and Mihai G. Netea


39 Intestinal Mononuclear Phagocytes in Health and Disease


Theodore J. Sanders, Ulf Yrlid, and Kevin J. Maloy


40 Strategies Used by Bacteria to Grow in Macrophages


Gabriel Mitchell, Chen Chen, and Daniel A. Portnoy


41 Mechanisms of Defense against Intracellular Pathogens Mediated by Human Macrophages


Barry R. Bloom and Robert L. Modlin


42 Myeloid Cells in Asthma


Bart N. Lambrecht, Emma Persson, and Hamida Hammad


43 Myeloid Cell Phenotypes in Susceptibility and Resistance to Helminth Parasite Infections


Rick M. Maizels and James P. Hewitson


44 Induction of Immunological Tolerance as a Therapeutic Procedure


Herman Waldmann, Duncan Howie, and Stephen Cobbold


SECTION VIII METABOLIC AND MALIGNANT DISEASE


45 Glutathione and Glutathione Transferase Omega 1 as Key Post-Translational Regulators in Macrophages


Mark M. Hughes, Anne F. McGettrick, and Luke A.J. O’Neill


46 Macrophages and Iron Metabolism


Tomas Ganz


47 Mechanisms of Myeloid Cell Modulation of Atherosclerosis


Filip K. Swirski, Matthias Nahrendorf, and Peter Libby


48 Macrophages in Endocrine Glands with Emphasis on Pancreatic Islets


Emil R. Unanue


59 Tumor-Induced Myeloid-Derived Suppressor Cells


Francesco De Sanctis, Vincenzo Bronte, and Stefano Ugel


50 Myeloid Cell Origins, Differentiation, and Clinical Implications


Kipp Weiskopf, Peter J. Schnorr, Wendy W. Pang, Mark P. Chao, Akanksha Chhabra, Jun Seita, Mingye Feng, and Irving L. Weissman


Index