Cytokines in Severe Sepsis and Septic Shock
Springer Basel (Verlag)
978-3-7643-5877-8 (ISBN)
Induction.- Inducers.- Endotoxin as an inducer of cytokines.- Acute lung inflammation in septic shock of the cytokine release induced by bacterial superantigens.- Lipopolysaccharide signaling pathways and their role in the development of the systemic inflammatory response syndrome.- Predisposing factors.- Predisposing factors: Effect of sex, nutritional factors and age on immunity following shock and sepsis.- Genetics: Cytokine polymorphisms.- Diagnostic.- Possibilities and problems of cytokine measurements.- Soluble TNF receptors.- Relevance of surrogate tests in intensive care patiens or "Heisenberg at the ICU".- Actions (selected events).- Nitric oxide and endothelin-1 in circulatory shock involving cytokines.- Multistep processes in neutrophil homotypic aggregation and tissue injury.- Cytokines, coagulation and fibrinolysis.- Apoptosis: Its role in the systemic inflammatory response syndrome and the involvement of cytokines.- Importance of cytokine metabolism for malnutrition, catabolism and endocrinological state in sepsis.- Therapy.- Endotoxin scavengers as a therapeutic strategy for sepsis.- Interfering with the production of cytokines in sepsis.- Neutralizing antibodies and receptor constructs.- Immunomodulation following shock and sepsis.- Gene therapy - an alternative approach for anti-cytokine therapies.- The failure of clinical trials in sepsis.- The failure of clinical trials in sepsis: Challenges of pre-clinical models.- The failure of clinical trials in sepsis: Challenges of clinical trial design.
Erscheint lt. Verlag | 1.11.1998 |
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Reihe/Serie | Progress in Inflammation Research |
Zusatzinfo | XX, 372 p. |
Verlagsort | Basel |
Sprache | englisch |
Maße | 170 x 244 mm |
Gewicht | 1610 g |
Themenwelt | Medizin / Pharmazie ► Allgemeines / Lexika |
Schlagworte | clinical trial • Cytokine • gene therapy • Genetics • Hardcover, Softcover / Medizin/Allgemeines • HC/Medizin/Pharmazie • Immunologie • Immunomodulation • inflammation • Intensive care • Metabolism • Nutrition • Pharmakologie • Research • Sepsis • shock • therapy • tissue |
ISBN-10 | 3-7643-5877-7 / 3764358777 |
ISBN-13 | 978-3-7643-5877-8 / 9783764358778 |
Zustand | Neuware |
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