Advances in Heterocyclic Chemistry

Part of a serial, this volume is intended for organic and medicinal chemists. Features include references and an index, and a cumulative subject index for Volumes 46 - 54.

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This volume surveys the chemistry and heterocyclic syntheses of aminomethylenemalonates and their cyclic sters. Early reviews in this field merely touched on certain aspects of the related chemistry. This is the first in-depth systematic treatment of the subject. The material is of particular importance in medicinal chemistry as derivatives of aminomethylene malonates are key intermediates in the synthesis of antimalarial agents. The literature reviewed has led to the discovery of nalidixic acid and its derivatives, norfloxacin and ciprofloxacin, as well as the new quinolones that are active against AIDS-related Legionella spp.