NSAIDs and Aspirin (eBook)

Prof. Angel Lanas graduated in medicine from the University of Zaragoza, in Zaragoza, Spain, in 1979. He completed postgraduate training in internal medicine at Zaragoza’s University Hospital and was awarded his doctor of medicine degree from the University of Zaragoza in 1984. Prof. Lanas took a position as a research fellow at the same university before working as a gastroenterologist staff member at various Spanish hospitals between 1986 and 1999. From 1989 to 1991, Prof. Lanas also joined the Department of Gastroenterology at the University of Alabama at Birmingham, in Birmingham, Alabama, as a visiting professor. He returned to Spain in 1992 as an associate professor of medicine at the University of Zaragoza. In 1999 he became clinical chief of gastroenterology at the University Hospital and in 2006 professor of medicine at the University of Zaragoza.  Since 1987, Prof. Lanas has been the recipient of multiple research grants from various Spanish funding bodies. He has also received grants from private foundations and companies for research mainly focused on the adverse effects of various drugs, especially nonsteroidal anti-inflammatory drugs, on the gastrointestinal tract. He is affiliated with multiple national and international gastroenterological associations and is or has been a member of different executive committees for various international studies. Since 2000, he has published more than 80 research and review publications in the field of gastroenterology. Prof. Lanas’ research interests include acid-, H. pylori- and NSAID-related gastrointestinal diseases. Chemoprevention of GI cancer

Section 1. Pharmacology and MechanismsChapter 1. Chemistry, Pharmacodynamics, and Pharmacokinetics of NSAIDsSara Calatayud and Juan Vicente EspluguesChapter 2. Principles, Mechanisms of Action, and Future Prospects of Anti-Inflammatory DrugsBibiana Rius and Joan Clària Section 2. Clinical Effects and Drug SafetyChapter 3. Efficacy of NSAIDs in the Treatment of Rheumatic DiseasesMarc C. Hochberg and Lee S. SimonChapter 4.  Adverse Effects of NSAIDs in the Gastrointestinal Tract: Risk Factors of Gastrointestinal Toxicity with NSAIDsSunny H. Wong and Francis K.L. ChanChapter 5. Adverse Effects of NSAIDs on the Cardiovascular SystemCarmelo Scarpignato and Corrado BlandizziChapter 6.  Safe Prescription of NSAIDs in Clinical PracticeMohammad Yaghoobi and Richard H. HuntSection 3. AspirinChapter 7. NSAIDS and Aspirin: Recent Advances and Implications for Clinical ManagementKarsten Schrör and Michael VoelkerChapter 8. Non-Prescription Analgesic Anti-inflammatory Drugs: Efficacy and SafetyDenis M. McCarthyChapter 9. Low-Dose Aspirin in the Cardiovascular SystemRuben Casado-Arroyo, Angel Lanas, and Pedro BrugadaChapter 10. Adverse Effects of Low-Dose Aspirin in the Gastrointestinal TractKatsunori IijimaChapter 11. Aspirin in the Treatment and Prevention of Cardiovascular Disease: Need for Individual Clinical JudgmentsAngel Lanas and Charles H. HennekensSection 4. NSAIDS and Aspirin in Cancer PreventionChapter 12. Molecular and Experimental Basis for COX-Inhibition in CancerAnnalisa Bruno, Melania Dovizio, and Paola PatrignaniChapter 13. Clinical Effects of NSAIDs and Coxibs in Colon Cancer PreventionElena Piazuelo and Angel LanasChapter 14. Aspirin and the Prevention of Colorectal Cancer Paul J. Lochhead and Andrew T. ChanChapter 15. A Rational Approach for the Use of NSAIDs and/or Aspirin in Cancer Prevention in the Near Future: “Balancing Risk and Benefits”Elizabeth Half, Ahmad Fokra, and Nadir Arber