Hepatocellular Carcinoma (eBook)

Dr. Brian I. Carr is Professor of Medical Oncology, Thomas Jefferson University, Philadelphia and Professor, IRCCS de Bellis, National Institute for Digestive Diseases, Castellana Grotte (BA), Italy. Since 1977 he has devoted both his clinical activities and research science efforts to the clinical and scientific study of primary liver cancer (HCC or hepatocellular carcinoma). He has published more than 250 papers in peer-reviewed journals, over 350 abstracts and given a similar number of meeting presentations, written chapters in 36 books and edited 2 books. He is guest editor for the HCC special issue of Seminars in Oncology, Aug, 2012 and has written the chapter on HCC for the last 2 editions of Harrison’s Internal Medicine.

Part A. Causes, Biological and Molecular bases of HCCChapter 1. Epidemiology of Hepatocellular Carcinoma - Donna L. White, Fasiha Kanwal, Li Jiao and Hashem B. El-SeragChapter 2. Environmental Carcinogens and Risk for Human Liver Cancer - John D. GroopmanChapter 3. Molecular Mechanisms of Hepatocellular Carcinoma - Hani Alotaibi, Nese Atabey, Kasım Diril, Esra Erdal and Mehmet OzturkChapter 4. Chemically-Induced Hepatocarcinogenesis - Yvonne P. DraganChapter 5. Molecular Profiling of Human Hepatocellular Carcinoma - Anuradha Budhu and Xin Wei WangChapter 6. Genomic signatures of risk factors and molecular identification of HCC subtypes - Jean-Charles Nault and Jessica Zucman-Rossi Chapter 7. MicroRNAs and hepatocellular carcinoma - Aldo CavalliniChapter 8. Non-tumor prognostic factors in hepatocellular carcinoma - Nicolas Goossens, Ismail Labgaa and Augusto Villanueva         Chapter 9. Gut microbiota and HCC - Sven H. Loosen, Christoph Roderburg and Tom LueddeChapter 10. Hepatocellular Carcinoma as a Paradigm for a Systemic Evolutionary Approach to Cancer - Antonio Mazzocca, Giovanni Ferraro, Giovanni Misciagna and Brian I. CarrChapter 11. HCC and its Microenvironment - Brian I. CarrChapter 12. Circulating tumor cells (Liquid Tumor Biopsy) in hepatocellular carcinoma: biology, methodologies, and clinical implications - Zhengfen YinChapter 13.  Role of the immune system in hepatocellular carcinoma: Implications for existing and novel therapies - Tobias Flecken and Robert ThimmeChapter 14. Inter- and Intratumor Heterogeneity in Hepatocellular Carcinoma - Evgeny V. Denisov, Tatiana S. Gerashchenko, Marina V. Zavyalova, Vasiliy N. Manskikh, Evgeny L. Choinzonov, Nadezhda V. Cherdyntseva and Vladimir M. PerelmuterChapter 15. Systemic inflammation: a new prognostic domain and source of therapeutic targets in hepatocellular carcinoma - David J. Pinato and Rohini SharmaChapter 16. Hepatocellular Carcinoma Associated with Hepatitis B virus - Inbal Houri and Oren ShiboletChapter 18. Obesity, NASH and HCC - Chadia L. Robertson, Devanand Sarkar and Arun J. SanyalChapter 19. Metabolic Disease and Hepatocellular Carcinoma - David H. Van Thiel, Salamah Mohammad Alwahsh and Giuliano RamadoriPart B. DiagnosisChapter 20. Pathologic Aspects of Hepatocellular Tumors - Michael A. Nalesnik Chapter 21. Protein biomarkers in the management of hepatocellular carcinoma: Novel combinatory approaches - Philip Johnson and Sarah BerhaneChapter 22. Surveillance for hepatocellular carcinoma - Cristina Della Corte and Massimo ColomboChapter 23. Use of Imaging Techniques to Screen for Hepatocellular Carcinoma - Satoshi GoshimaChapter 24. Ultrasound of Hepatocellular Carcinoma: The Important Contribution of Contrast Enhancement - Tae Kyoung Kim, Hyun-Jung Jang and Stephanie R. WilsonChapter 25. MRI for Detection and Evaluation of Hepatocellular Carcinoma - Anuj Patel, Neil Malhotra, Christopher G. Roth, Sandeep Deshmukh and Donald G. MitchellChapter 26. Computed Tomography of HCC - Francesco Agnello and Giuseppe BrancatelliChapter 27. Clinical features and clinician's diagnostic approach to hepatocellular carcinoma - Tamar Thurm and Oren ShiboletChapter 28. Current HCC Staging systems: their uses and limitations - Yukio Tokumitsu and Hiroaki NaganoPart C. TherapiesChapter 29. Percutaneous Ethanol Injection - Tito Livraghi, Maria Franca Meloni and Anita AndreanoChapter 30. Thermal Ablative Treatments For Hepatocellular Carcinoma - Antonio Facciorusso and Michele BaroneChapter 31. Resection of Hepatocellular Carcinoma - Nir Lubezky, Yaacov Goykhman, Richard Nakache and Ido Nachmany               Chapter 32. Liver Transplantation for Hepatocellular Carcinoma - Georg Györi, Pierre-Alain Clavien and Mickaël LesurtelChapter 33. Medical Therapy of HCC - Brian I. Carr, Srikanth Nagalla and Ravit Geva             Chapter 34. Targeted therapies for Hepatocellular Carcinoma - Susan Kralian and Brian I. CarrChapter 35. Radiation Therapy for Hepatocellular Carcinoma - Andrew S. Kennedy       Chapter 36. Psychosocial Issues in Hepatocellular carcinoma - Jennifer L. Steel, Feridey N. Carr, Alexandra Savkova, Naadia Ahmed, Andrea DiMartini and Mary A. DewChapter 37. Bringing it all together - Brian I. Carr