Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy (eBook)

Christopher D. Gregory is Professor of Inflammatory Cell Biology and the Deputy Director of the MRC Centre for Inflammation Research at the University of Edinburgh. Professor Gregory is an active research group leader in the fields of immunology, inflammation, and cancer with a particular interest in apoptosis. He has published over 100 scientific papers and has received over 6,950 citations.

Foreword.- Preface.- 1. Molecular Cell Biology of Apoptosis and Necroptosis in Cancer.- 2. Clearance of Dying Cells by Phagocytes: Mechanisms and Implications for Disease Pathogenesis.- 3. Micro-environmental Effects of Cell Death in Malignant Disease.- 4. Apoptotic Caspases in Promoting Cancer: Implications from Their Roles in Development and Tissue Homeostasis.- 5. Axl and Mer Receptor Tyrosine Kinases: Distinct and Non-overlapping Roles in Inflammation and Cancer?.- 6. Immunogenic Apoptotic Cell Death and Anti-cancer Immunity.- 7. Cancer Cell Death-inducing Radiotherapy – Impact on Local Tumour Control, Tumour Cell Proliferation and Induction of Systemic Anti-tumour Immunity.- 8. Novel Approaches to Apoptosis-inducing Therapies.- 9. Killing Is Not Enough – How Apoptosis Hijacks Tumor-associated Macrophages to Promote Cancer Progression.- Index.