Bone Metastases

Preface. I Fundamental Concepts.- Pathophysiology of metastatic bone disease.- Bone metastases: epidemiology, clinical picture, SREs and prognosis.- Pain in bone metastases: types and mechanisms. II Investigations Of Bone Metastases.- Radiological evaluations: radiography, CT, MRI.- Nuclear medicine imaging modalities: bone scintigraphy, PET-CT, SPECT.- Bone turnover markers.- New omics approaches for bone metastases. III Therapeutic Management.- Analgesic treatment for bone mets.- Radiotherapy: external beam and radio-surgery.- Radionuclide therapy.- Bisphosphonates.- New targeted therapies for bone metastases.- Chemotherapy and hormone therapy.- HIFU/Radioablation.- Neuropathic bone metastases.- Spinal cord compression and cauda equina compression.- Pathological and impending fracture.- Re-irradiation.- Bone metastases in elderly patients.- Management of metastatic bone disease in the elderly with bisphosphonates and RANKL inhibitors: effectiveness and safety. IV Assesment of Therapeutic Response.- Radiological and nuclear medicine imaging modalities.- Clinical assessment measures.- Outcome measures in bone metastases clinical trials.- Quality of life in patients suffering from metastatic skeletal disease. V Cost of Managing Metastatic Bone Disease.- Cost effectiveness of treatment modalities for bone metastases.- Index.