William Dameshek and Frederick Gunz's Leukemia

Part 1 Introduction: leukemia in the past; definition and classification. Part 2 Nature of leukemia: pathophysiology; clonal development and stem cell origin of leukemias and related disorders; kinetics of leukemia and control of cell division and replication; immunology; cytogenetics of leukemic cells; ultrastructure of leukemic cells; pathology of leukemia. Part 3 Etiology of leukemia: etiology of leukemia - a persisting puzzle; descriptive epidemiology of the leukemias; human retroviruses, leukemia, and AIDS; ionizing radiation and human leukemia; chemicals and leukemia. Part 4 Diagnosis of leukemia: clinical manifestation and diagnosis; morphology and cytochemistry. Part 5 Treatment of leukemia: treatment terminology and overview; principles of chemotherapy - drugs and biochemical determinants; marrow transplantation in the treatment of leukemia; the treatment of acute lymphoblastic leukemia; the treatment of acute myelogenous leukemia; the management of chronic myeloid leukemia; chronic lymphocytic leukemia; primary myelodysplastic syndrome and secondary preleukemic disorders; prolymphocytic and hairy cell leukemias; adult T-cell leukemia. Part 6 Complications of leukemia: complications - a selective overview; infection in the leukemia patient - diagnosis, therapy and prevention; hemostasis and thrombosis in acute and chronic leukemia; central nervous system leukemia; psychological complications of leukemia.