The Heart in Rheumatic, Autoimmune and Inflammatory Diseases

Udi Nussinovitch, MD, PhD has mainly dedicated his research to cardiac autoimmunity and autoinflammation, cardiac manifestations of systemic diseases, cell- and gene-based cardiac therapies, and the modulation of the cardiac electrophysiologic substrate for therapeutic purposes. He has published articles in leading rheumatologic and cardiovascular journals. He has also published several chapters in scientific textbooks, mostly dealing with cardiac autoimmunity. Dr Nussinovitch has been the recipient of several awards and serves as a reviewer for prestigious rheumatologic and cardiac journals. Dr Nussinovitch carries out his clinical work at the Rambam Healthcare Campus, a tertiary medical facility and leading referral center in northern Israel, academically affiliated to the Technion Institute of Technology, Israel.

Part I. Immune Medicated Cardiac Injury, Accelerated Atherosclerosis and the Study of Cardiac Involvements in Systemic Diseases 1. Pathophysiology of Autoimmunity and Immune-Mediated Mechanisms in Cardiovascular Diseases 2. Organ-Specific Autoimmune Myocardial Diseases: From Pathogenesis to Diagnosis and Management 3. Autoantibodies Directed Against G-Protein-Coupled Receptors in Cardiovascular Diseases: Basics and Diagnostics 4. Immune-Mediated Accelerated Atherosclerosis 5. A Study of Cardiac Function, Atherosclerosis, and Arrhythmogenicity

Part II. Cardiac Manifestations of Inflammatory Arthritis 6. Rheumatoid Arthritis 7. Juvenile Idiopathic Arthritis 8. Spondyloarthritides: Ankylosing Spondylitis, Psoriatic Arthritis, and Reactive Arthritis 9. Polymyalgia Rheumatica

Part III. Cardiac Involvement in Autoimmune and Connective Tissue Diseases 10. Systemic Lupus Erythematosus 11. Neonatal Lupus 12. Sjögren’s Syndrome 13. Systemic Sclerosis 14. Dermatomyositis and Polymyositis

Part IV. Cardiac Manifestations Crystal-Induced Arthritis 15. Gout

Part V. Cardiac Manifestations of Large Vessel Vasculitides 16. Giant Cell Arteritis 17. Takayasu’s Arteritis

Part VI. Cardiac Manifestations of Medium Vessel Vasculitides 18. Polyarteritis Nodosa 19. Kawasaki Disease

Part VII. Cardiac Manifestations of Small Vessel Vasculitides 20. ANCA-Associated Vasculitis: Microscopic Polyangiitis, Eosinophilic Granulomatosis With Polyangiitis (Churg–Strauss Syndrome) and Granulomatosis With Polyangiitis (Wegener’s Granulomatosis)

Part VIII. Cardiac Manifestations of Variable Vessel Vasculitides 21. Behçet’s Disease

Part IX. Post-Infectious Autoimmune Cardiac Diseases 22. Rheumatic Fever and Rheumatic Heart Disease 23. Chagas Cardiomyopathy

Part X. Autoinflammation 24. Familial Mediterranean Fever

Part XI. Therapeutic Approaches: Mechanisms of Action and Cardiac Effects 25. Desirable and Adverse Effects of Antiinflammatory Agents on the Heart 26. The Effects of Immunosuppressive and Cytotoxic Drugs on the Heart 27. Autoantibody-Directed Therapy in Cardiovascular Diseases 28. Cardiac Immunomodulation